Darolutamide in Addition to Standard Androgen Deprivation Therapy and Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

1,306

Participants

Timeline

Start Date

November 30, 2016

Primary Completion Date

October 25, 2021

Study Completion Date

April 11, 2023

Conditions
Metastatic Hormone-sensitive Prostate Cancer
Interventions
DRUG

BAY1841788 / darolutamide (ODM-201)

600mg (2 tablets of 300 mg) of darolutamide (ODM-201)/placebo twice daily with food, equivalent to a total a daily dose of 1200 mg in addition to standard ADT (luteinizing hormone releasing hormone (LHRH) agonist/antagonist or orchiectomy) and 6 cycles of docetaxel

DRUG

Standard ADT (androgen deprivation therapy)

As prescribed by the treating physician.

DRUG

Docetaxel

As prescribed by the treating physician.

DRUG

Placebo

Placebo matching darolutamide (ODM-201) tablets in appearance, bid orally with food, in addition to standard ADT (luteinizing hormone releasing hormone \[LHRH\] agonist/antagonist or orchiectomy) and 6 cycles of docetaxel.

Trial Locations (300)

100

Taipei

1000

Bruxelles - Brussel

1070

Brussels

1200

Bruxelles - Brussel

1303

Sofia

1431

Sofia

1784

Sofia

2010

Sydney

2031

Randwick

2610

Wilrijk

3000

Vratsa

3065

Fitzroy

3080

Seoul

5000

Adelaide

Namur

5037

Kurralta Park

5300

Gabrovo

5809

Pleven

6000

Charleroi

6273

Seoul

6351

Seoul

7120

Palma de Mallorca

8036

Barcelona

9000

Ghent

9010

Varna

10003

Cáceres

10032

New York

10034

Prague

10043

Turin

11217

Taipei

11923

Gyeonggi-do

12203

Berlin

12601

Poughkeepsie

13273

Marseille

13620

Seongnam-si

14004

Córdoba

14203

Buffalo

14642

Rochester

15212

Pittsburgh

17011

Camp Hill

17176

Stockholm

18107

Rostock

19004

Bala-Cynwyd

20141

Milan

20520

Turku

21204

Towson

21231

Baltimore

22031

Fairfax

22908

Charlottesville

25030

Besançon

27003

Lugo

27157

Winston-Salem

28034

Madrid

28041

Madrid

28100

Novara

29010

Málaga

29200

Brest

29406

North Charleston

29414

Charleston

29572

Myrtle Beach

29607

Greenville

30322

Atlanta

33076

Bordeaux

33305

Taoyuan District

33486

Boca Raton

33521

Tampere

34298

Montpellier

35128

Padua

35760

Saint-Grégoire

37134

Verona

38100

Trento

38126

Braunschweig

39120

Magdeburg

40138

Bologna

40202

Louisville

40447

Taichung

40620

Jyväskylä

43126

Parma

43210

Columbus

44106

Cleveland

44805

Saint-Herblain

46009

Valencia

47392

Busan

48149

Münster

48202

Detroit

49055

Angers

51726

Reims

53226

Milwaukee

54100

Nancy

59102

Billings

60611

Chicago

61469

Gwangju

62290

Cuernavaca

63011

Clermont-Ferrand

64460

Monterrey

67033

Strasbourg

69495

Pierre-Bénite

70112

New Orleans

70210

Kuopio

72076

Tübingen

72622

Nürtingen

73104

Oklahoma City

75231

Dallas

76000

Querétaro City

76508

Temple

79106

Freiburg im Breisgau

82110

Mazatlán

84112

Salt Lake City

85224

Chandler

85724

Tucson

86021

Poitiers

87109

Albuquerque

89075

Ulm

90220

Oulu

91010

Duarte

91054

Erlangen

94010

Créteil

94805

Villejuif

95303

Cergy-Pontoise

98201

Everett

100034

Beijing

100050

Beijing

100083

Beijing

100142

Beijing

100730

Beijing

110001

Shenyang

110042

Shengyang

115478

Moscow

125284

Moscow

130061

Changchun

188663

Saint Petersburg

194017

Saint Petersburg

197136

Saint Petersburg

200000

Shanghai

200032

Shanghai

200040

Shanghai

200072

Shanghai

200080

Shanghai

200092

Shanghai

210000

Nanjing

210008

Nanjing

230031

Hefei City, Anhui Province

250012

Jinan

250021

Jinan

264000

Yantai

300000

Tianjin

300052

Tianjin

310009

Hangzhou

310014

Hangzhou

325000

Wenzhou

330006

Nanchang

361003

Xiamen

400030

Chongqing

410013

Changsha

430030

Wuhan

430079

Wuhan

450000

Zhengzhou

454048

Chelyabinsk

454087

Chelyabinsk

510120

Guangzhou

630099

Novosibirsk

644013

Omsk

656045

Barnaul

700721

Daegu

710061

Xi'an

807377

Kaohsiung City

1311001

Safed

3109601

Haifa

4941492

Petah Tikva

5822012

Holon

6423906

Tel Aviv

7030000

Zrifin

8410101

Beersheba

9112001

Jerusalem

90211-1850

Beverly Hills

90073-1003

Los Angeles

94305-5820

Stanford

20007-2113

Washington D.C.

32610-0316

Gainesville

33612-9416

Tampa

61615-7828

Peoria

02111

Boston

02114-2696

Boston

02215

Boston

68130-5606

Omaha

03756

Lebanon

08143

Camden

07361

Englewood

07601

Hackensack

10467-2490

The Bronx

43214-2416

Columbus

45409-1328

Kettering

29401-5799

Charleston

23298-5054

Richmond

29308-020

Cachoeiro de Itapemirim

41253-190

Salvador

81520-060

Curitiba

59062-000

Natal

90050 170

Porto Alegre

09060-650

Santo André

04014-002

São Paulo

20231-050

Rio de Janeiro

22793-080

Rio de Janeiro

T2N 4N2

Calgary

T6G 1Z2

Edmonton

M4N 3M5

Toronto

M5G 2M9

Toronto

H2L 4M1

Montreal

050000

Shijiazhuang

602 00

Brno

656 91

Brno

120 00

Prague

128 08

Prague

150 06

Prague

180 81

Prague

00290

Helsinki

FIN-50100

Mikkeli

07747

Jena

00152

Rome

466-8560

Nagoya

036-8563

Hirosaki

289-2511

Asahi

277-8577

Kashiwa

285-8741

Sakura

791-0280

Matsuyama

003-0804

Sapporo

650-0017

Kobe

920-8530

Kanazawa

920-8641

Kanazawa

761-0793

Kita

232-0024

Yokohama

241-8515

Yokohama

514-8507

Tsu

980-8574

Sendai

634-8522

Kashihara

589-8511

Sayama

565-0871

Suita

431-3192

Hamamatsu

329-0498

Shimotsuke

321-0974

Utsunomiya

113-8431

Bunkyo-ku

113-8603

Bunkyo-ku

113-8655

Bunkyo-ku

135-8550

Koto-ku

152-8902

Meguro-ku

105-8471

Minato-ku

181-8611

Mitaka

164-8541

Nakano-ku

160-8582

Shinjuku-ku

162-8543

Shinjuku-ku

683-8504

Yonago

755-8505

Ube

260-8677

Chiba

260-8717

Chiba

811-1395

Fukuoka

500-8717

Gifu

860-0008

Kumamoto

889-1692

Miyazaki

852-8501

Nagasaki

700-8558

Okayama

541-8567

Osaka

545-8586

Osaka

770-8503

Tokushima

641-8510

Wakayama

06760

Mexico City

México, D. F.

1066 CX

Amsterdam

1081 HV

Amsterdam

3318 AT

Dordrecht

6162 BG

Geleen

1213 XZ

Hilversum

2134 TM

Hoofddorp

2545 AA

The Hague

5042 AD

Tilburg

90-302

Lodz

20-362

Lublin

44-200

Rybnik

08-110

Siedlce

05-135

Waliszew

02-781

Warsaw

02841

Seoul

03722

Seoul

06591

Seoul

138-736

Seoul

08208

Sabadell

08003

Barcelona

08023

Barcelona

08041

Barcelona

413 45

Gothenburg

221 85

Lund

901 85

Umeå

751 85

Uppsala

CO45JR

Colchester

RM7 0AG

Romford

TS43BW

Middlesbrough

BT9 7AB

Belfast

G12 0YN

Glasgow

NW1 2BU

London

SW3 6JJ

London

W6 8RF

London

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Orion Corporation, Orion Pharma

INDUSTRY

lead

Bayer

INDUSTRY

NCT02799602 - Darolutamide in Addition to Standard Androgen Deprivation Therapy and Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer | Biotech Hunter | Biotech Hunter