Evaluation of the Efficacy, Safety, and Tolerability of Sarizotan in Rett Syndrome With Respiratory Symptoms

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

October 26, 2016

Primary Completion Date

August 6, 2019

Study Completion Date

May 4, 2020

Conditions
Rett Syndrome
Interventions
DRUG

Sarizotan low dose

2 mg or 5 mg bid based on age and weight criteria for 24 wks DB 2 mg bid (4 to \<13 years; ≥13 years of age and weighing \<25 kg; 5 mg bid (≥13 years of age and weighing ≥25 kg). Assessment of safety, tolerability and efficacy on reducing the respiratory symptoms in patients.

DRUG

Sarizotan high dose

5 mg or 10 mg bid based on age and weight criteria for 24 wks DB 5 mg bid (4 to \<13 years; ≥13 years of age and weighing \<25 kg; 10 mg bid (≥13 years of age and weighing ≥25 kg) Assessment of safety, tolerability and efficacy on reducing the respiratory symptoms in patients

DRUG

Placebo

Placebo BID followed by assessment of safety, tolerability and efficacy on reducing the respiratory symptoms in patients.

Trial Locations (14)

6961

South Metropolitan Health Service Fiona Stanley Hospital, Murdoch

20142

U.O. Neuropsichiatria Infantile, Milan

35233

University of Alabama, Birmingham

53100

A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena

55101

Gillette Children's Specialty Healthcare, Saint Paul

60612

Rush University Medical Center, Chicago

77030

Baylor College of Medicine, Houston

92093

University of California, San Diego

682041

Amrita Institute of Medical Sciences, Kochi

600 026

Vijaya Health Centre, Chennai

400 016

P.D. Hinduja National Hospital and Medical Research Centre, Mumbai

400 026

Jaslok Hospital and Research centre, Mumbai

110 029

All India Institute of Medical Sciences, New Delhi

SE5 8AF

King's College Hospital, London

Sponsors
All Listed Sponsors
lead

Newron Pharmaceuticals SPA

INDUSTRY

NCT02790034 - Evaluation of the Efficacy, Safety, and Tolerability of Sarizotan in Rett Syndrome With Respiratory Symptoms | Biotech Hunter | Biotech Hunter