Safety Testing of Adding Nivolumab to Chemotherapy in Patients With Intermediate and High-Risk Local-Regionally Advanced Head and Neck Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

September 25, 2018

Study Completion Date

February 21, 2022

Conditions
Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions
DRUG

Nivolumab

Anti-PD-1 targeted immunotherapy

DRUG

Cisplatin

Anti-cancer alkylating agent

DRUG

Cetuximab

Epidermal Growth Factor Receptor (EGFR) antagonist

RADIATION

IMRT

High-precision radiotherapy

Trial Locations (11)

15232

UPMC - Shadyside Hospital, Pittsburgh

22042

Inova Fairfax Hospital, Falls Church

30322

Emory University/Winship Cancer Institute, Atlanta

32806

University of Florida Cancer Center at Orlando Health, Orlando

40202

University of Louisville, Louisville

43210

Ohio State University, Columbus

44106

University Hospitals Cleveland Medical Center, Cleveland

53792

University of Wisconsin Hospital and Clinics, Madison

77030

MD Anderson Cancer Center, Houston

94304

Stanford Cancer Institute, Palo Alto

97213

Providence Portland Medical Center, Portland

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

RTOG Foundation, Inc.

OTHER