Evaluation of the Effect of Acetazolamide, Mannitol and N-acetylcysteine on Cisplatin-Induced Nephrotoxicity

patients received acetazolamide 250 mg half an hour before cisplatin with saline hydration.for prevention of cisplatin nephrotoxicity

patients received NAC (600 mg every 12 hours) for 4 doses beginning 24 hours before cisplatin with saline hydration.for prevention of cisplatin nephrotoxicity

patients received mannitol 20 % 100 ml half an hour before cisplatin and saline hydration.

saline hydration 2500 ml before cisplatin therapy

patients with tumours already prescribed cisplatin