A Study of Itacitinib (INCB039110) in Combination With Ibrutinib in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

December 29, 2016

Primary Completion Date

June 6, 2022

Study Completion Date

June 6, 2022

Conditions
Lymphoma
Interventions
DRUG

itacitinib

Phase 1 will evaluate itacitinib at the protocol-specified starting dose, with a possible increase or decrease depending on tolerability. Phase 2 will evaluate the recommended dose determined in Phase 1.

DRUG

ibrutinib

Trial Locations (21)

10065

Memorial Sloan Kettering Cancer Center, New York

14263

Roswell Cancer Center, Buffalo

17822

Geisinger Medical Center, Danville

19104

University of Pennsylvania Health System, Philadelphia

21201

University of Maryland Cancer Center, Baltimore

30912

Georgia Regents Research Institute, Augusta

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

43623

Toledo Clinic Cancer Centers, Toledo

48109

University of Michigan Cancer Center, Ann Arbor

48910

Michigan State University Breslin Cancer Center, Lansing

59102

St Vincent Frontier Cancer Center, Billings

74146

Tulsa Cancer Center, Tulsa

77030

Houston Methodist Cancer Center, Houston

85259

Mayo Clinic Arizona, Scottsdale

89169

Comprehensive Cancer Center of Nevada, Las Vegas

90033

LAC-USC Medical Center/Kenneth Norris Jr Cancer Hospital, Los Angeles

90813

Pacific Shores Medical Group, Long Beach

91010

City of Hope National Medical Center, Duarte

92093

Moores UC San Diego Cancer Center, San Diego

98373

Northwest Medical Specialists & Research Institute, Puyallup

07739

Regional Cancer Center Associates, LLC, Little Silver

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY