Improving Risk Assessment of AML With a Precision Genomic Strategy to Assess Mutation Clearance

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

107

Participants

Timeline

Start Date

July 6, 2016

Primary Completion Date

July 31, 2029

Study Completion Date

July 31, 2029

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Cytarabine

PROCEDURE

Allogeneic stem cell transplant

PROCEDURE

Bone marrow aspiration

"* Baseline~* Approximately 30 days after cytotoxic induction therapy~* End of treatment"

PROCEDURE

Punch skin biopsy

"* The first will be obtained with the initial blood and bone marrow collections, whenever possible.~* The second will be obtained at the time of re-biopsy to confirm remission."

DEVICE

ClinSeq

Clinical Sequencing to determine clearance or persistence of leukemia-associate mutations performed at MGI CLIA lab

Trial Locations (3)

14642

University of Rochester, Rochester

32608

University of Florida, Gainesville

63110

Washington University School of Medicine, St Louis

All Listed Sponsors
collaborator

The Leukemia and Lymphoma Society

OTHER

collaborator

American Society of Hematology

OTHER

lead

Washington University School of Medicine

OTHER