A Phase 3 Study of Pembrolizumab + Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma (Keynote-252 / ECHO-301)

PHASE3CompletedINTERVENTIONAL
Enrollment

706

Participants

Timeline

Start Date

June 21, 2016

Primary Completion Date

January 8, 2018

Study Completion Date

August 16, 2019

Conditions
Melanoma
Interventions
DRUG

pembrolizumab + epacadostat

"* Pembrolizumab will be administered intravenously every 3 weeks starting at Day 1 (Week 1)~* Epacadostat will be administered orally daily starting at Day 1 (Week 1)"

DRUG

pembrolizumab + placebo

"* Pembrolizumab will be administered intravenously every 3 weeks starting at Day 1 (Week 1)~* Placebo will be administered orally daily starting at Day 1 (Week 1)"

Trial Locations (129)

Unknown

Birmingham

Scottsdale

Little Rock

Los Angeles

San Francisco

Santa Barbara

Santa Monica

Aurora

Denver

Washington D.C.

Fort Lauderdale

Jacksonville

Ocala

West Palm Beach

Chicago

Peoria

Iowa City

Kansas City

Lutherville

Boston

Ann Arbor

Fridley

Billings

Omaha

Las Vegas

Rochester

Charlotte

Philadelphia

Nashville

Austin

Dallas

Salt Lake City

Fairfax

Spokane

Camperdown

Westmead

Wollstonecraft

Cairns

Greenslopes

Kurralta Park

Melbourne

Brussels

Ghent

North Vancouver

Ottawa

Toronto

Montreal

Santiago

Viña del Mar

Aarhus

Herlev

Odense C

Bordeaux

Lille

Marseille

Paris

Pierre-Bénite

Reims

Rennes

Toulouse

Villejuif

Buxtehude

Essen

Hanover

Kiel

Tübingen

Cork

Dublin

Galway

Ramat Gan

Bergamo

Genova

Milan

Napoli

Padua

Siena

Susono

Asahikawa

Chūō

Fukuoka

Kagoshima

Kumamoto

Kurume

Kyoto

Matsumoto

Nagoya

Niigata

Okayama

Osaka

Sapporo

Sendai

Tokyo

Tsukuba

Chihuahua City

Distrito Federal

Mexico City

Monterrey

Amsterdam

Nijmegen

Dunedin

Tauranga

Warsaw

Istra

Moscow

Saint Petersburg

Johannesburg

Sandton

Groenkloof

Cape Town

Kraaifontein

Seoul

Donostia / San Sebastian

A Coruña

Barcelona

Donostia / San Sebastian

Madrid

Pamplona

Seville

Valencia

Gothenburg

Lund

Stockholm

Uppsala

Zurich

Geneva

Lausanne

Edinburgh

London

Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Incyte Corporation

INDUSTRY