An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Reflux

NATerminatedINTERVENTIONAL
Enrollment

161

Participants

Timeline

Start Date

May 31, 2016

Primary Completion Date

October 31, 2019

Study Completion Date

October 31, 2019

Conditions
Gastroesophageal Reflux Disease (GERD)Reflux, GastroesophagealGastroesophageal RefluxAcid Reflux
Interventions
PROCEDURE

Laparoscopic implantation surgery

Laparoscopic surgery to implant the pulse generator and bipolar lead.

DEVICE

EndoStim stimulation for first six months of study

Lower esophageal stimulation

DEVICE

EndoStim stimulation from Month 6 thru end of study

Lower esophageal stimulation

DEVICE

Sham EndoStim stimulation for first six months of study

"EndoStim device remains off (no stimulation delivered)"

Trial Locations (21)

10021

Cornell University Weill Medical College, New York

10032

Columbia University Medical Center, New York

15224

Allegheny Health Network Research Institute, Pittsburgh

23298

Virginia Commonwealth University, Richmond

27599

University of North Carolina, Chapel Hill

28260

Carolinas HealthCare System, Charlotte

33606

University of South Florida, Tampa

37212

Vanderbilt University Medical Center, Nashville

43210

The Ohio State University Medical Center, Columbus

44109

The MetroHealth System, Cleveland

78665

Baylor Scott & White Research Institute, Round Rock

80113

Institute of Esophageal and Reflux Surgery, Englewood

85013

St. Joseph's Hospital and Medical Center, Phoenix

85258

HonorHealth Research Institute, Scottsdale

90033

University of Southern California (USC), Los Angeles

94305

Stanford Center for Clinical Research, Stanford

97213

Oregon Clinic, Portland

97239

Oregon Health Science University, Portland

Unknown

Universitaire Ziekenhuizen Leuven, Leuven

Clinical Trial Center Maastricht, Maastricht

University College London, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

EndoStim Inc.

INDUSTRY