Study of Ibrutinib in Combination With Bendamustine and Rituximab for Patients With Relapsed/Refractory Aggressive BCL

PHASE2UnknownINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

June 30, 2020

Study Completion Date

October 31, 2021

Conditions
Diffuse Large B Cell LymphomaPrimary Mediastinal (Thymic) Large B-cell LymphomaTransformed Indolent LymphomaRecurrent DiseaseRefractory Cancer
Interventions
DRUG

Bendamustine 90 mg/m2 IV on Days 1-2, Cycles 1-6

"Therapy initiation 30 days max from screening.~Bendamustine 90 mg/m2 IV on Days 1-2, Cycles 1-6 Rituximab 375 mg/m2 IV Day 1, Cycles 1-6; a cycle is defined as 28 days Ibrutinib, 560 mg orally, once daily, continuously starting on Cycle 1, Day 1 until disease progression, toxicity or referral for allo-SCT"

Trial Locations (2)

5262179

NOT_YET_RECRUITING

Dr. Meirav Kedmi, Ramat Gan

Unknown

RECRUITING

Sheba medical organization, Ramat Gan

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Johnson & Johnson

INDUSTRY

lead

Meirav Kedmi MD

OTHER_GOV