2,927
Participants
Start Date
September 20, 2016
Primary Completion Date
December 31, 2019
Study Completion Date
December 31, 2019
Isoniazid
Participants in the Treatment Arm will receive high dose Isoniazid - 15mg per kg body weight, rounded up to the nearest 100 mg; maximum dose 900 mg with Pyridoxine supplementation (25mg).
Rifapentine
Rifapentine based on body weight (\>32kg - 50kg: 750 mg; \>50kg: 900 mg), given weekly as 12 directly observed treatment (DOT) oral doses, ideally with food, over 3 months.
Aurum Institute, Klerksdorp
Centre for the Aids Programme of Research in South Africa (CAPRISA), Durban
South African Tuberculosis Vaccine Initiative (SATVI), Worcester
Stellenbosch Immunology Research Group, Cape Town
Aurum Institute, Rustenburg
Collaborators (1)
South African Tuberculosis Vaccine Initiative
OTHER
Aurum Institute
OTHER
Centre for the AIDS Programme of Research in South Africa
NETWORK
University of Stellenbosch
OTHER
London School of Hygiene and Tropical Medicine
OTHER
Fred Hutchinson Cancer Center
OTHER
University of Cape Town
OTHER