Memory Improvement Through Nicotine Dosing (MIND) Study

PHASE2CompletedINTERVENTIONAL
Enrollment

348

Participants

Timeline

Start Date

January 13, 2017

Primary Completion Date

August 25, 2025

Study Completion Date

September 16, 2025

Conditions
Mild Cognitive Impairment
Interventions
DRUG

Nicotine Transdermal Patch

21mg Nicotine transdermal patches worn during waking hours. Active dose will titrate up from 3.5mg to 21mg in the first 6 weeks of treatment, remain at 21mg for 22.5 months, and then taper down in the final month of treatment.

DRUG

Placebo Patch

Matching placebo patches worn during waking hours.

Trial Locations (36)

11229

Integrative Clinical Trials, New York

13057

Velocity Clinical Research - Syracuse, East Syracuse

13210

SUNY Upstate Medical University, Syracuse

14203

University at Buffalo (UBMD), Buffalo

17033

Penn State Hershey Medical Center, Hershey

18105

LeHigh Valley Hospital, Allentown

27157

Wake Forest University Health Sciences, Winston-Salem

30912

Augusta University Movement and Memory Disorders, Augusta

33137

Miami Jewish Health Systems, Miami

33445

Brain Matters Research, Delray Beach

33462

JEM Research Institute, Atlantis

34997

Brain Matters Research, Stuart

37212

Vanderbilt University Medical Center, Nashville

38018

Neurology Clinic, P.C., Cordova

43210

Ohio State University, Columbus

52242

University of Iowa, Iowa City

53706

University of Wisconsin, Madison

72205

Central Arkansas Veterans Healthcare System, North Little Rock

74104

Central States Research (formerly Tulsa Clinical Research), Tulsa

77030

Houston Methodist Neurological Institute, Houston

78229

Glenn Biggs Institute at the University of Texas Health, San Antonio

83642

Velocity Clinical Research - Boise, Meridian

85254

Perseverance Research Center, Scottsdale

90242

USC Rancho Los Amigos, Downey

92123

Sharp Neurocognitive Research Center, San Diego

92705

Syrentis Clinical Research, Santa Ana

97225

Providence Brain and Spine Institute, Portland

98195

University of Washington Memory and Brain Wellness Center, Seattle

99202

Kingfisher Cooperative, LLC, Spokane

100166055

New York University Medical Center, New York

100296552

Mount Sinai School of Medicine, New York

200072145

Georgetown University, Washington D.C.

294011113

Ralph H. Johnson VA Health Care System, Charleston

606113010

Northwestern University, Chicago

06810

Nuvance Health Medical Practice Ct, Inc.; Associated Neurologists, PC, Danbury

02360

Headlands Eastern MA LLC, Plymouth

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

collaborator

Vanderbilt University

OTHER

collaborator

Alzheimer's Therapeutic Research Institute

OTHER

lead

University of Southern California

OTHER