348
Participants
Start Date
January 13, 2017
Primary Completion Date
August 25, 2025
Study Completion Date
September 16, 2025
Nicotine Transdermal Patch
21mg Nicotine transdermal patches worn during waking hours. Active dose will titrate up from 3.5mg to 21mg in the first 6 weeks of treatment, remain at 21mg for 22.5 months, and then taper down in the final month of treatment.
Placebo Patch
Matching placebo patches worn during waking hours.
Integrative Clinical Trials, New York
Velocity Clinical Research - Syracuse, East Syracuse
SUNY Upstate Medical University, Syracuse
University at Buffalo (UBMD), Buffalo
Penn State Hershey Medical Center, Hershey
LeHigh Valley Hospital, Allentown
Wake Forest University Health Sciences, Winston-Salem
Augusta University Movement and Memory Disorders, Augusta
Miami Jewish Health Systems, Miami
Brain Matters Research, Delray Beach
JEM Research Institute, Atlantis
Brain Matters Research, Stuart
Vanderbilt University Medical Center, Nashville
Neurology Clinic, P.C., Cordova
Ohio State University, Columbus
University of Iowa, Iowa City
University of Wisconsin, Madison
Central Arkansas Veterans Healthcare System, North Little Rock
Central States Research (formerly Tulsa Clinical Research), Tulsa
Houston Methodist Neurological Institute, Houston
Glenn Biggs Institute at the University of Texas Health, San Antonio
Velocity Clinical Research - Boise, Meridian
Perseverance Research Center, Scottsdale
USC Rancho Los Amigos, Downey
Sharp Neurocognitive Research Center, San Diego
Syrentis Clinical Research, Santa Ana
Providence Brain and Spine Institute, Portland
University of Washington Memory and Brain Wellness Center, Seattle
Kingfisher Cooperative, LLC, Spokane
New York University Medical Center, New York
Mount Sinai School of Medicine, New York
Georgetown University, Washington D.C.
Ralph H. Johnson VA Health Care System, Charleston
Northwestern University, Chicago
Nuvance Health Medical Practice Ct, Inc.; Associated Neurologists, PC, Danbury
Headlands Eastern MA LLC, Plymouth
Collaborators (1)
National Institute on Aging (NIA)
NIH
Vanderbilt University
OTHER
Alzheimer's Therapeutic Research Institute
OTHER
University of Southern California
OTHER