An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

116

Participants

Timeline

Start Date

May 5, 2016

Primary Completion Date

April 14, 2022

Study Completion Date

April 14, 2022

Conditions
Solid Tumors and Hematologic Malignancy
Interventions
DRUG

INCB059872

"Initial cohort dose of INCB059872 monotherapy at the protocol-specified starting dose, with subsequent cohort escalations based on protocol-specific criteria. The recommended dose(s) will be taken forward into expansion cohorts.~INCB059872 tablets to be administered by mouth."

DRUG

all-trans retinoic acid (ATRA)

DRUG

azacitidine

DRUG

nivolumab

Trial Locations (15)

10027

Columbia University, New York

14263

Roswell Park Cancer Institute, Buffalo

19104

University of Pennsylvania, Philadelphia

35487

University of Alabama, Birmingham

37240

Vanderbilt University, Nashville

60208

Northwestern University, Chicago

66045

University of Kansas Center for Research, Inc., Kansas City

77030

University of Texas MD Anderson Cancer Center, Houston

90095

UCLA Medical Center, Los Angeles

92093

Moores UCSD Cancer Center, La Jolla

97297

Oregon Health Science University, Portland

Unknown

Institut Jules Bordet, Brussels

Netherland Cancer Institute, Amsterdam

VU Medical Center, Amsterdam

Erasmus MC, Rotterdam

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY