Randomized Phase 2 Study of Atezolizumab and Entinostat in Patients With aTN Breast Cancer With Phase 1b Lead In

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

May 31, 2016

Primary Completion Date

March 31, 2021

Study Completion Date

March 31, 2021

Conditions
Breast Cancer
Interventions
DRUG

Entinostat

An orally available histone deacetylases inhibitor (HDAC).

DRUG

Atezolizumab

A humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death ligand 1 (PD-L1).

DRUG

Placebo

A pill containing no active drug ingredient

Trial Locations (29)

4600

Saint Nikolozi Surgery and Oncological Centre, Kutaisi

Unimed Adjara - Oncology Center, Kutaisi

Research Institute of Clinical Medicine, Tbilisi

6010

Cancer Center of Adjara Autonomous Republic, Batumi

27157

Wake Forest Baptist Medical Center, Winston-Salem

28806

Hope Women's Cancer Centers, Asheville

32806

Orlando Health, Inc., Orlando

33020

Office of Human Research, Hollywood

35201

UAB Comprehensive Cancer Center, Birmingham

46804

Ft. Wayne Hematology and Oncology, Fort Wayne

46845

Ft. Wayne Medical Oncology & Hematology, Inc, Fort Wayne

55426

Frauenshuh Cancer Center at Park Nicollet Health Service, Saint Louis Park

67214

Cancer Center of Kansas, Wichita

75201

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas

81501

Saint Mary's Regional Cancer Center, Grand Junction

90277

Torrance Memorial Cancer Care Associates, Redondo Beach

90404

UCLA Hematology/Oncology - Santa Monica, Santa Monica

91204

Los Angeles Hematology Oncology Medical Group, Glendale

92835

St. Jude Medical Center, Fullerton

93309

CBCC Global Research at Comprehensive Blood and Cancer Center, Bakersfield

93401

SLO Oncology and Hematology Health Center, San Luis Obispo

93454

Central Coast Medical Oncology Group, Santa Maria

07039

Saint Barnabas Medical Cancer Center, Livingston

0144

Health House, Tbilisi

0159

Institute of Clinical Oncology, Tbilisi

New Vision University Hospital, Tbilisi

0177

Cancer Research Center, Tbilisi

0179

S. Khechinashvili, University Hospital, Tbilisi

0186

Multiprofile Clinic Consilium Medulla, Tbilisi

Sponsors
All Listed Sponsors
collaborator

Roche Pharma AG

INDUSTRY

lead

Syndax Pharmaceuticals

INDUSTRY