72
Participants
Start Date
July 1, 2016
Primary Completion Date
June 11, 2021
Study Completion Date
June 11, 2021
Ibrutinib
Participants will receive Ibrutinib (dose 240 mg/m\^2 /329 mg/m\^2 per day) during part 1 and part 2.
Rituximab
Participants will receive a cumulative dose of rituximab 750 mg/m\^2 as a part of RICE/RVICI regimen in part 1 and part 2 per cycle.
Ifosfamide
Participants will receive a cumulative dose of Ifosfamide 9 g/m\^2 and 10 g/m\^2 as a part of RICE and RVICI regimen respectively in part 1 and part 2 per cycle.
Carboplatin
Participants will receive a cumulative dose of carboplatin 635 mg/m\^2 and 800 mg/m\^2 as a part of RICE and RVICI regimen respectively in part 1 and part 2 per cycle.
Etoposide
Participants will receive a cumulative dose of etoposide 300 mg/m\^2 in part 1 and part 2 as a part of RICE regimen per cycle.
Vincristine
Participants will receive a cumulative dose of vincristine 1.6 mg/m\^2 in part 1 and part 2 as a part of RVICI regimen per cycle.
Idarubicin
Participants will receive a cumulative dose of idarubicin 20 mg/m\^2 in part 1 and part 2 as a part of RVICI regimen per cycle.
Dexamethasone
Participants will receive a cumulative dose of dexamethasone 100 mg/m\^2 in part 1 and part 2 as a part of RICE/RVICI regimen per cycle.
Los Angeles
Orange
Palo Alto
Aurora
Washington D.C.
Atlanta
Baltimore
Boston
New York
Valhalla
Charlotte
Cincinnati
Columbus
Philadelphia
Dallas
Salt Lake City
Milwaukee
Brussels
Leuven
Barretos
Curitiba
São Paulo
Plovdiv
Sofia
Halifax
Toronto
Brno
Prague
Bordeaux
Lille
Lyon
Marseille
Nantes
Toulouse
Vandœuvre-lès-Nancy
Villejuif
Berlin
Freiburg im Breisgau
Kiel
München
Münster
Budapest
Debrecen
Rotterdam
Utrecht
Krakow
Warsaw
Wroclaw
Bucharest
Cluj-Napoca
Oradea
Timișoara
Moscow
Saint Petersburg
Yekaterinburg
Seoul
Barcelona
Esplugues de Llobregat
Madrid
Valencia
Gothenburg
Kaohsiung City
Taipei
Taoyuan District
Ankara
Izmir
Kiev
Birmingham
Cambridge
Leeds
Liverpool
London
Manchester
Newcastle
Sheffield
Surrey
Collaborators (1)
Pharmacyclics LLC.
INDUSTRY
Janssen Research & Development, LLC
INDUSTRY