Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee

PHASE3CompletedINTERVENTIONAL
Enrollment

698

Participants

Timeline

Start Date

January 21, 2016

Primary Completion Date

December 5, 2017

Study Completion Date

May 14, 2018

Conditions
Osteoarthritis, KneeOsteoarthritis, Hip
Interventions
OTHER

Placebo

Patient receives one dose of placebo to match tanezumab subcutaneously on Day 1 and one dose of placebo to match tanezumab subcutaneously at Week 8.

BIOLOGICAL

Tanezumab 2.5 mg

Patient receives one dose of tanezumab 2.5 mg subcutaneously on Day 1 and one dose of tanezumab 2.5 mg subcutaneously at Week 8.

BIOLOGICAL

Tanezumab 2.5mg/5mg

Patient receives one dose of tanezumab 2.5 mg subcutaneously on Day 1 and one dose of tanezumab 5 mg subcutaneously at Week 8.

Trial Locations (87)

10530

Drug Trials America, Hartsdale

16801

University Orthopedics Center, State College

23294

National Clinical Research - Richmond, Inc, Richmond

23320

Center for Arthritis and Rheumatic Diseases, Chesapeake

24541

Spectrum Medical, Inc, Danville

27612

Wake Research Associates, LLC, Raleigh

29601

Palmetto Clinical Trial Services, LLC, Greenville

30331

Atlanta Center for Medical Research, Atlanta

30501

Center for Advanced Research & Education (CARE), Gainesville

32162

Bioclinica Research, The Villages

32174

Ormond Beach Clinical Research, Ormond Beach

32806

Compass Research, LLC, Orlando

33013

Eastern Research, Inc., Hialeah

33135

South Florida Research Center, Inc., Miami

33175

New Horizon Research Center, Miami

33176

Miami Dade Medical Research Institute, LLC, Miami

33321

Phoenix Clinical Research, LLC, Tamarac

33912

Clinical Physiology Associates, Fort Myers

35235

Alabama Orthopaedic Surgeons, Birmingham

35242

Cahaba Research, Inc., Birmingham

37211

Quality Medical Research, Nashville

39232

Arthritis and Osteoporosis Treatment and Research Center, Flowood

44883

AC Clinical Research, Tiffin

45005

Prestige Clinical Research, Franklin

46112

Investigators Research Group, LLC, Brownsburg

48307

Michigan Orthopaedic & Spine Surgeons, Rochester Hills

50265

Integrated Clinical Trial Services, Inc., West Des Moines

57702

Health Concepts, Rapid City

58104

Plains Clinical Research Center, LLC, Fargo

60602

Medex Healthcare Research Inc, Chicago

60607

Chicago Clinical Research Institute, Inc., Chicago

60611

Northwestern University Feinberg School of Medicine, Chicago

60640

Great Lakes Clinical Trials, Chicago

70115

George Stanley Walker, MD, New Orleans

72205

Baptist Health Center for Clinical Research, Little Rock

73109

NPC Research, Oklahoma City

73119

Hillcrest Clinical Research, Oklahoma City

75024

The Pain Relief Center, Plano

75231

Arthritis Care and Diagnostic Center, Dallas

76012

KRK Medical Research, Arlington

76117

T&R Clinic, PA, Fort Worth

77058

Centex Studies, Inc., Houston

77084

BI Research Center, Houston

77521

Urgent Care MD's, Baytown

78745

Tekton Research, Inc, Austin

80301

Alpine Clinical Research Center, Boulder

85023

Arizona Research Center, Phoenix

85374

Clinical Research Institute of Arizona, LLC, Surprise

85714

Tucson Orthopaedic Institute, Tucson

85724

University of Arizona Clinical and Translational Science Research Center, Tucson

87106

New Mexico Clinical Research & Osteoporosis Center, Inc., Albuquerque

89144

Office Of Stephen H. Miller, M.D., Las Vegas

91606

Providence Clinical Research, North Hollywood

91722

Medvin Clinical Research, Covina

91786

Inland Rheumatology Clinical Trials, Inc., Upland

92103

Artemis Institute for Clinical Research, San Diego

92123

California Research Foundation, San Diego

92614

Irvine Center for Clinical Research, Irvine

92618

Robert L Freed, M.D., F.A.C.R / Clinical Interventions Research Institute, Irvine

92805

Advanced Research Center, Inc, Anaheim

92835

St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare, Fullerton

96814

East-West Medical Research Institute, Honolulu

98007

Northwest Clinical Research Center, Bellevue

06606

New England Research Associates, LLC, Bridgeport

06905

Stamford Therapeutics Consortium, Stamford

67205-1138

Professional Research Network of Kansas, LLC, Wichita

02760

Tristan Medical Enterprises, PC dba Regeneris Medical, North Attleboro

07728

Arthritis And Osteoporosis Associates, Freehold

L6T 0G1

Aggarwal and Associates Limited, Brampton

L7R 1A4

Manna Research Inc. (Burlington south), Burlington

N1H 1B1

Dawson Road Medical Centre, Guelph

L8N 1Y2

Adachi Medicine Professional Corporation, Hamilton

N2M 5N6

K-W Musculoskeletal Research Inc., Kitchener

N6G 2M1

Western Center for Public Health and Family Medicine, London

L4V 1P1

Malton Medical Centre, Mississauga

L6K 1J6

Rebecca Medical Associates, Oakville

L1H 1G6

King Street Medical Clinic, Oshawa

N7T 4X3

Bluewater Clinical Research Group, Sarnia

H2Y 1S1

Diex Recheche Montreal, Inc., Montreal

G1G 3Y8

Recherche Clinique Sigma inc, Québec

G1S 2L6

Diex Recherche Quebec Inc., Québec

G1V 3M7

G.R.M.O. (Groupe de recherche en maladies osseuses) Inc., Québec

G1W 4R4

Centre de recherche Saint-Louis, Québec

G3K 2P8

Alpha Recherche Clinique, Québec

J1L 0H8

Diex Research Sherbrooke Inc., Sherbrooke

00717

Puerto Rico Medical Research Inc., Ponce

00918

Mindful Medical Research, San Juan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02697773 - Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee | Biotech Hunter | Biotech Hunter