Losartan Effects on Emphysema Progression

PHASE4CompletedINTERVENTIONAL
Enrollment

220

Participants

Timeline

Start Date

May 23, 2017

Primary Completion Date

March 31, 2021

Study Completion Date

June 30, 2021

Conditions
Emphysema
Interventions
DRUG

Losartan

50mg once per day for two weeks,followed by 100mg once per day for 46 weeks if increased dose tolerated

DRUG

Placebo

one capsule per day for two weeks, followed by two capsules per day for 46 weeks

Trial Locations (28)

10016

New York University School of Medicine, New York

10021

Weill Cornell Medicine, New York

10029

Mount Sinai National Jewish Health Respiratory Institute; Icahn School of Medicine, New York

10032

Columbia University Medical Center, New York

15213

University of Pittsburgh Medical Center, Pittsburgh

19140

Temple University, Philadelphia

27710

Duke University Medical Center, Durham

32209

University of Florida College of Medicine, Jacksonville

33613

University of South Florida, Tampa

35249

University of Alabama at Birmingham, Birmingham

46260

St. Vincent Hospital and Health Care Center, Inc., Indianapolis

60608

University of Illinois at Chicago, Chicago

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

60637

University of Chicago Hospitals, Chicago

63104

St. Louis University School of Medicine, St Louis

63110

St. Louis Asthma Clinical Research Center - Washington University School of Medicine, St Louis

66160

University of Kansas Medical Center, Kansas City

70112

Louisiana State University, New Orleans

77030

Baylor College of Medicine, Houston

80206

National Jewish Medical and Research Center, Denver

85724

University of Arizona, Tucson

92103

University of California at San Diego, San Diego

94143

University of California at San Francisco, San Francisco

98108

Pacific Northwest Airways - VA Puget Sound Healthcare System, Seattle

06810

Western Connecticut Health Network, Danbury

48109-5360

University of Michigan, Ann Arbor

05466

Vermont Lung Center at The University of Vermont, Colchester

All Listed Sponsors
collaborator

University of Pittsburgh

OTHER

lead

JHSPH Center for Clinical Trials

OTHER