Fulvestrant (F)+Placebo vs F+Palbociclib First Line for Postmenopausal Hormone Receptor+ Advanced Breast Cancer

PHASE2UnknownINTERVENTIONAL
Enrollment

189

Participants

Timeline

Start Date

February 17, 2016

Primary Completion Date

January 11, 2020

Study Completion Date

December 31, 2023

Conditions
Breast Neoplasms
Interventions
DRUG

PD-0332991 (Palbociclib)

"Palbociclib, 125 mg, orally once daily from day 1 to day 21 followed by 7 days off treatment on every 28 days cycles.~Patients will continue to receive their assigned treatment until objective disease progression, clinical progression (under investigator criteria), unacceptable toxicity, death or withdrawal of consent, whichever occurs first"

DRUG

Fulvestrant

"Fulvestrant 500mg, two 5ml intramuscular injections (one in each buttock), on days 1, 15 (±3 days) of Cycle 1, and then on Day 1 of each subsequent 28 day cycle (±3 days)~Patients will continue to receive their assigned treatment until objective disease progression, clinical progression (under investigator criteria), unacceptable toxicity, death or withdrawal of consent, whichever occurs first"

DRUG

Placebo

"Placebo orally once daily from day 1 to day 21 followed by 7 days off treatment on every 28 days cycles.~Patients will continue to receive their assigned treatment until objective disease progression, clinical progression (under investigator criteria), unacceptable toxicity, death or withdrawal of consent, whichever occurs firs"

Trial Locations (32)

14004

Hospital Universitario Reina Sofía, Córdoba

15009

Centro Oncológico de Galicia, A Coruña

23007

Complejo Hospitalario de Jaén, Jaén

24080

Complejo Asistencial Universitario de León, León

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Clínico Universitario San Carlos, Madrid

28223

Hospital Universitario Quirón de Madrid, Pozuelo de Alarcón

28492

Hospital Universitario de Fuenlabrada, Madrid

28981

Hospital Universitario Infanta Cristina, Parla

29011

Hospital Regional Universitario de Málaga, Málaga

33011

Hospital Universitario Central de Asturias, Oviedo

36204

Complejo Hospitalario Universitario Vigo, Vigo

41009

Hospital Universitario Virgen de la Macarena, Seville

41013

Hospital Quirón Sagrado Corazón de Sevilla, Seville

Hospital Universitario Vírgen del Rocío, Seville

41014

Hospital Universitario de Valme, Seville

43204

Hospital Universitario Sant Joan Reus, Reus

46010

Hospital Clínico Universitario de Valencia, Valencia

46014

Hospital General Universitario Valencia, Valencia

46026

Hospital Universitario I Politècnic La Fe, Valencia

50009

Hospital Universitario Miguel Servet, Zaragoza

Unknown

Bon Secours Hospital, Cork

Beaumont Hospital, Dublin

Mater Misericordiae University Hospital, Dublin

Galway University Hospital, Galway

University Hospital Waterford, Waterford

07120

Hospital Universitari Son Espases, Palma de Mallorca

07198

Hospital Son Llàtzer, Palma de Mallorca

08221

Hospital Universitario Mutua Terrassa, Terrassa

08003

Hospital del Mar, Barcelona

08026

Hospital de la Santa Creu y Sant Pau, Barcelona

08916

Hospital Universitario Germans Trias i Pujol, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Spanish Breast Cancer Research Group

OTHER