8
Participants
Start Date
May 31, 2013
Primary Completion Date
September 30, 2014
Study Completion Date
September 30, 2014
Positron-Emission Tomography
Dynamic scanning is performed for 60 minutes. Image acquisition is performed in 3D and reconstructed using an iterative OSEM VUEPOINT algorithm
11C-5-HTP
150-400 MBq \[11C\]5-HTP (approximately 2-5 MBq/kg) is administered manually as an intravenous bolus in a intravenous catheter in the arm prior to PET imaging.
Magnetic Resonance Imaging
Analysis will focus on adipose tissue distribution and composition in the liver.
Mixed-Meal Tolerance Test (MMTT)
Continuous Glucose Monitoring System® (CGMS)
CGMS involves the subcutaneous (SC) placement of a glucose sensor connected by tubing to a pager-sized monitoring device that stores glucose data. Subjects will have the sensor placed in the clinic and wear it continuously for 72 - 84 hours (Gold) or 72-144 hours (iPro2).
Glomerular Filtration Rate Testing
Blood draw
Karolinska University Hospital, Stockholm
Uppsala University, Uppsala
National Institute of Allergy and Infectious Diseases (NIAID)
NIH