Combination Margetuximab and Pembrolizumab for Advanced, Metastatic HER2(+) Gastric or Gastroesophageal Junction Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

January 31, 2016

Primary Completion Date

January 31, 2021

Study Completion Date

January 31, 2021

Conditions
Gastric CancerStomach CancerEsophageal Cancer
Interventions
BIOLOGICAL

Margetuximab 10 mg/kg

Margetuximab treatment is administered intravenously (IV) once every 21-day cycle

BIOLOGICAL

Margetuximab 15 mg

Margetuximab treatment is administered IV once every 21-day cycle

BIOLOGICAL

Pembrolizumab

Pembrolizumab treatment is administered IV once every 21-day cycle

Trial Locations (28)

19107

Fox Chase Cancer Center, Philadelphia

20007

Georgetown University-Lombardi Comprehensive Cancer Center, Washington D.C.

21231

Johns Hopkins University Medical Center, Baltimore

21565

Gachon University Gil Medical Center, Incheon

27710

Duke University Medical Center, Durham

37203

Sarah Cannon Research Institute, Nashville

41404

Kyungbuk National University Hospital, Daegu

48201

Karmanos Cancer Institute, Detroit

54907

Chonbuk National University Hospital, Seoul

60637

University of Chicago, Chicago

63110

Washington University School of Medicine, St Louis

98104

Swedish Cancer Institute, Seattle

06520

Yale School of Medicine, New Haven

02215

Dana-Farber Cancer Institute/Harvard University Medical Center, Boston

L8V5C2

Juravinski Cancer Centre - McMaster University, Hamilton

H4A3J1

McGill University Health Centre, Montreal

Unknown

National Cancer Centre, Singapore

National University Hospital, Singapore

Raffles Hospital, Singapore

Asan Medical Center, Seoul

Korea University Anam Hospital, Seoul

Korea University Guro Hospital, Seoul

Samsung Medical Center, Seoul

Seoul National University Bundang Hospital, Seoul

Seoul National University Hospital, Seoul

National Taiwan University Hospital, Taipei

Taipei Veterans General Hospital, Taipei

Tri-Service General Hospital, Taipei

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

MacroGenics

INDUSTRY

NCT02689284 - Combination Margetuximab and Pembrolizumab for Advanced, Metastatic HER2(+) Gastric or Gastroesophageal Junction Cancer | Biotech Hunter | Biotech Hunter