Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis

PHASE2CompletedINTERVENTIONAL
Enrollment

318

Participants

Timeline

Start Date

January 26, 2016

Primary Completion Date

January 29, 2019

Study Completion Date

February 28, 2019

Conditions
Non-alcoholic SteatohepatitisFibrosisLiver Diseases
Interventions
DRUG

Emricasan (5 mg)

Subjects with Non-alcoholic Steatohepatitis (NASH) Fibrosis will be administered orally with emricasan (5 mg) twice a day.

DRUG

Emricasan (50 mg)

Subjects with Non-alcoholic Steatohepatitis (NASH) Fibrosis will be administered orally with emricasan (50 mg) twice a day.

DRUG

Placebo

Subjects with Non-alcoholic Steatohepatitis (NASH) Fibrosis will be administered orally with a matching placebo twice a day.

Trial Locations (103)

10003

Mount Sinai Beth Israel Medical Center, New York

10016

NYU Langone Medical Center, New York

10032

Columbia University Medical Center (CUMC), New York

10065

Weill Cornell Medical College, New York

10467

Montefiore Medical Center, The Bronx

11030

Northwell Health, Inc., Manhasset

13353

Charité - Universitätsmedizin Berlin, Berlin

14203

State University of New York, Buffalo

19104

Hospital of the University of Pennsylvania, Philadelphia

19107

Thomas Jefferson University, Philadelphia

19140

Temple University Hospital, Philadelphia

19141

Albert Einstein Medical Center, Philadelphia

20014

Hospital Universitario de Donostia, Donostia / San Sebastian

20016

Sibley Memorial Hospital, Washington D.C.

20059

Howard University, Washington D.C.

20246

Universitätsklinikum Hamburg Eppendorf, Hamburg

20889

Walter Reed National Military Medical Center, Bethesda

21202

Mercy Medical Center, Baltimore

23249

McGuire VA Medical Center, Richmond

23502

Digestive and Liver Disease Specialists, Norfolk

23602

Bon Secours Richmond Health System, Newport News

27607

Rex Healthcare, Raleigh

27710

Duke University Medical Center, Duke South Clinics, Durham

28006

Hospital Universitario de La Princesa, Madrid

28007

Hospital General Universitario Gregorio Marañon, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28046

Hospital Universitario La Paz, Madrid

28204

Carolinas Healthcare System, Center for Liver Disease, Charlotte

28222

Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda

28801

Asheville Gastroenterology Associates, PA, Asheville

29425

Medical University of South Carolina, Charleston

29461

PMG Research at Charleston, Charleston

30030

iResearch Atlanta LLC, Decatur

30060

Gastrointestinal Specialists of Georgia, Marietta

30625

Medizinische Hochschule Hannover, Hanover

32610

UF Hepatology Research at CTRB, Gainesville

32804

Florida Hospital Orlando Transplant Institute, Orlando

33125

Miami Veterans Administration Healthcare System, Miami

33136

University of Miami/Schiff Center for Liver Diseases, Miami

33606

Tampa General Medical Group, Tampa

34211

Florida Digestive Health Specialist, Lakewood Rch

35233

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt University Medical Center - Digestive Disease Center, Nashville

37421

ClinSearch, LLC, Chattanooga

38104

Methodist University Hospital, Memphis

38138

Gastro One, Germantown

39008

Hospital Universitario Marques de Valdecilla, Santander

40202

University of Louisville, Louisville

44106

University Hospitals Case Medical Center, Cleveland

45249

Consultants for Clinical Research, Cincinnati

46010

Hospital Clinico Universitario de Valencia, Valencia

46104

Hospital General Universitario de Valencia, Valencia

47150

Aquiant Research, New Albany

48149

Universitätsklinikum Münster, Münster

48202

Henry Ford Health System, Detroit

50309

UnityPoint Clinic Center For Liver Disease, Des Moines

50325

Iowa Digestive Disease Center, P.C, Clive

52074

Universitätsklinikum der RWTH Aachen, Aachen

53127

Universitätsklinikum Bonn, Bönning

55131

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz

55905

Mayo Clinic, Rochester

60611

Northwestern Memorial Hospital, Chicago

60612

Rush University Medical Center, Chicago

60637

The University of Chicago Medical Center, Chicago

63110

Washington University School of Medicine-Infectious Disease Clinical Research Unit, St Louis

64128

Kansas City VA Medical Center, Kansas City

64131

Kansas City Research Institute, Kansas City

70121

Ochsner Clinic Foundation, New Orleans

71105

Louisiana Research Center, LLC, Shreveport

72211

Preferred Research Partners, Inc., Little Rock

74104

Options Health Research, LLC, Tulsa

75390

University of Texas Southwestern Medical Center, Dallas

76012

Texas Clinical Research Institute, Arlington

76104

Baylor All Saints Medical Center, Fort Worth

77030

Baylor College of Medicine, Houston

Liver Associates of Texas, P.A., Houston

Research Specialists of Texas, Houston

78215

American Research Corporation at the Texas Liver Institue, San Antonio

78219

Brooke Army Medical Center, San Antonio

78233

Pinnacle Clinical Research, PLLC, Live Oak

79106

Universitätsklinikum Freiburg, Freiburg im Breisgau

84132

University of Utah Health Sciences Center, Salt Lake City

85724

University of Arizona Clinical and Translational Sciences Research Center, Tucson

90024

UCLA The Pfleger Liver Institute, Los Angeles

90048

Cedars Sinai Medical Center, West Hollywood

90067

Gastrointestinal Biosciences, Los Angeles

91105

California Liver Research Institute, Pasadena

92103

University of California San Diego Medical Center, San Diego

92377

Inland Empire Liver Foundation, Rialto

92660

Surinder Singh Saini, M.D., Inc., Newport Beach

93701

Fresno Clinical Research Center, Freestone

95817

University of California Davis Medical Center, Sacramento

98104

University of Washington Harborview Medical Center, Seattle

06510

Yale University School of Medicine, New Haven

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

01803

Lahey Clinic Medical Center, Burlington

07103

Doctors Office Center, Newark

02905

University Gastroenterology, Providence

05405

University of Vermont, Burlington

04103

Eugastro GmbH, Leipzig

08035

Hospital Universitario Vall d'Hebron, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

Sponsors
All Listed Sponsors
lead

Conatus Pharmaceuticals Inc.

INDUSTRY

NCT02686762 - Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis | Biotech Hunter | Biotech Hunter