A Study To Assess The Tolerability And Clinical Activity Of Gedatolisib In Combination With Palbociclib/Letrozole Or Palbociclib/Fulvestrant In Women With Metastatic Breast Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

141

Participants

Timeline

Start Date

June 14, 2016

Primary Completion Date

January 19, 2022

Study Completion Date

January 19, 2022

Conditions
Breast Cancer
Interventions
DRUG

Gedatolisib

Gedatolisib weekly intravenous starting at 180 mg/week in a 4 week cycle.

DRUG

Palbociclib

Palbociclib initiated at 125 mg daily: 3 out of 4 weeks in a 4 week cycle.

DRUG

Letrozole

Letrozole at 2.5 mg daily

DRUG

Fulvestrant

Fulvestrant administered intramuscularly at 500 mg on Day 1, 15 and 28 and then every 28 days.

Trial Locations (41)

19107

Thomas Jefferson University - Clinical and Regulatory, Philadelphia

Thomas Jefferson University, Philadelphia

22031

Virginia Cancer Specialists, PC, Fairfax

27514

UNC Cancer Hospital Infusion Pharmacy, Chapel Hill

UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital, Atlanta

The Emory Clinic, Atlanta

Winship Cancer Institute, Atlanta

33612

Moffitt Cancer Center Richard M Schulze Family Foundation Outpatient Center at McKinley Campus, Tampa

Moffitt Cancer Center, Tampa

35233

University of Alabama at Birmingham, Birmingham

35249

University of Alabama at Birmingham, Birmingham

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Henry-Joyce Cancer Clinic, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

The Ohio State University Wexner Medical Center James Cancer Hospital, Columbus

43212

Stefanie Spielman Comprehensive Breast Cancer, Columbus

48109

University of Michigan, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

48334

Karmanos Cancer Institute, Farmington Hills

77030

The University of Texas MD Anderson Cancer Center, Houston

U.T. MD Anderson Cancer Center, Houston

80045

University of Colorado Hospital - Anschutz Inpatient Pavilion (AiP), Aurora

University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP), Aurora

University of Colorado Hospital - Clinical Trials Office (CTO), Aurora

University of Colorado Hospital- Anschutz Cancer Pavilion (ACP), Aurora

90033

Keck Hospital of USC - Norris Healthcare Center (HC3), Los Angeles

Keck Hospital of USC, Los Angeles

LAC+USC Medical Center, Los Angeles

USC/Norris Comprehensive Cancer Center / Investigational Drug Services, Los Angeles

USC/Norris Comprehensive Cancer Center, Los Angeles

92501

Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc., Riverside

92708

Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc., Fountain Valley

92879

Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc., Corona

94115

UCSF - Helen Diller Family Comprehensive Cancer Center, San Francisco

94158

UCSF - Helen Diller Family Comprehensive Cancer Center, San Francisco

98109

Seattle Cancer Care Alliance (SCCA) Investigational Drug Services, Seattle

Seattle Cancer Care Alliance, Seattle

98195

University of Washington Medical Center, Seattle

02114

Massachusetts General Hospital, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celcuity Inc

INDUSTRY

NCT02684032 - A Study To Assess The Tolerability And Clinical Activity Of Gedatolisib In Combination With Palbociclib/Letrozole Or Palbociclib/Fulvestrant In Women With Metastatic Breast Cancer | Biotech Hunter | Biotech Hunter