A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

130

Participants

Timeline

Start Date

June 3, 2016

Primary Completion Date

August 2, 2018

Study Completion Date

September 30, 2025

Conditions
Leukemia, Myeloid, Acute
Interventions
DRUG

AG-120

Specified dose on specified days

DRUG

Azacitidine

Specified dose on specified days

DRUG

AG-221

Specified dose on specified days

Trial Locations (49)

0

Local Institution - 401, Zurich

3141

Local Institution - 175, Melbourne

4031

Local Institution - 403, Basel

5530

Local Institution - UNK-121, Yvoir

6000

Local Institution - 177, Perth

10005

Local Institution - 376, Cáceres

10043

Local Institution - 251, Orbassano

10065

Local Institution - 106, New York

12200

Local Institution - 227, Berlin

13273

Local Institution - 206, Marseille

16132

Local Institution - 256, Genova

28007

Local Institution - 378, Madrid

28033

Local Institution - 381, Madrid

29010

Local Institution - 380, Málaga

31059

Local Institution - 203, Toulouse

31122

Local Institution - 250, Pesaro

33604

Local Institution - 204, Pessac

35128

Local Institution - 254, Padua

40138

Local Institution - 253, Bologna, Emilia-Romagna

46009

Local Institution - 377, Valencia

50134

Local Institution - 252, Florence

59037

Local Institution - 205, Lille

60611

Local Institution - 108, Chicago

60637

Local Institution - 103, Chicago

69495

Local Institution - 202, Pierre-Bénite

75475

Local Institution - 200, Paris

89081

Local Institution - 225, Ulm

94805

Local Institution - 201, Villejuif

91010-301

Local Institution - 105, Duarte

06510

Local Institution - 107, New Haven

02114

Local Institution - 102, Boston

02115

Beth Israel Deaconess Medical Center, Boston

Local Institution - 902, Boston

75390-85520

Local Institution - 110, Dallas

SA 5000

Local Institution - 178, Adelaide

M5G 2M9

Local Institution - 125, Toronto

01307

Local Institution - 230, Dresden

00189

Local Institution - 255, Roma

3584 CX

Local Institution - 277, Utrecht

1169-050

Local Institution - 327, Lisbon

135-710

Local Institution - 351, Seoul

138-736

Local Institution - 350, Seoul

08036

Local Institution - 379, Barcelona

08907

Local Institution - 375, Barcelona

413 45

Local Institution - UNK-52, Gothenburg

B15 2TH

Local Institution - 429, Birmingham

OX3 9DU

Local Institution - 427, Headington

SE5 9RS

Local Institution - 428, London

SM2 5PT

Local Institution - 430, Sutton (Surrey)

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY