289
Participants
Start Date
April 26, 2016
Primary Completion Date
June 22, 2018
Study Completion Date
June 22, 2018
Omega-3 fish oil
The Omega-3 fish oil will be provided in 700 mg gelcaps. The starting dose will be 1.4 g/day of fish oil and continue until the 6 month visit. If the average of IL-6 measured at 3- and 6-month visits does not decrease by \>40% vs. baseline (average of screening visits 1 and 2), we increase the dose to 2.8 g/day.
Losartan
The Losartan will be provided in 25 mg and 50 mg capsules. The starting dose will be 25 mg/day, if tolerated, then stepped up to 50 mg/day. If there are no safety concerns, a continuation of 50 mg/day will be provided until the 6 month visit. If the average of IL-6 measured at 3- and 6-month visits does not decrease by \>40% vs. baseline (average of screening visits 1 and 2), an increase to the dose of 100 mg/day.
Corn Oil (Fish oil Placebo)
The corn oil placebo gel caps will be identical in shape, color, taste and weight as the Omega-3 fish oil.
Cellulose Based (Losartan Placebo)
The placebo cellulose based capsules will be identical in shape, color, taste and weight as the losartan capsules.
University of Pittsburgh, Pittsburgh
Wake Forest University, Winston-Salem
University of Florida, Gainesville
Northwestern University, Chicago
Tufts University, Boston
Collaborators (1)
National Institute on Aging (NIA)
NIH
Abbott
INDUSTRY
University of Florida
OTHER