Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 1, 2017

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Sickle Cell Disease
Interventions
DRUG

Defibrotide

defibrotide will be given prophylactically prior to AlloSCT to determine if it decreases the incidence of SOS in this high risk population, and determine that it is safe and feasible to give along with myeloimmunoablative therapy and allogeneic transplant.

Trial Locations (4)

10595

RECRUITING

New York Medical College, Valhalla

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

90095

RECRUITING

University of California Los Angeles, Los Angeles

32610-0278

RECRUITING

University of Florida, Gainesville

Sponsors
All Listed Sponsors
collaborator

University of California, Los Angeles

OTHER

collaborator

Medical College of Wisconsin

OTHER

collaborator

Tufts Medical Center

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

Johns Hopkins University

OTHER

collaborator

Dana-Farber Cancer Institute

OTHER

collaborator

Children's Hospital Los Angeles

OTHER

lead

New York Medical College

OTHER