The Reduced Insulinotropic Effect of a Continuous Infusion Relative to a Bolus Injection of GIP

bolus injections of synthetic human GIP (50 pmol/kg body weight) administered 30 and 120 min after commencing the hyperglycemic clamp

hyperglycemic clamp with the continuous intravenous infusion of 2 pmol.kg-1.min-1 synthetic human GIP between 30 and 180 min

an oral glucose challenge (75 g)

a hyperglycemic clamp (capillary venous glucose concentration \~ 8.5 mmol/l)