Pharmacokinetic and Pharmacodynamic Study of Bococizumab Alone and When Combined With Recombinant Human Hyaluronidase

PHASE1TerminatedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 29, 2016

Primary Completion Date

July 31, 2016

Study Completion Date

July 31, 2016

Conditions
HealthyHypercholesterolemia
Interventions
BIOLOGICAL

Cohort 1: bococizumab 150 mg + rHuPH20

bococizumab 150 mg + rHuPH20 administered SC to healthy volunteers

BIOLOGICAL

Cohort 2: bococizumab 300 mg

bococizumab 300 mg administered SC to healthy volunteers

BIOLOGICAL

Cohort 3: bococizumab 300 mg + rHuPH20

bococizumab 300 mg + rHuPH20 administered SC to healthy volunteers

BIOLOGICAL

Cohort 5: bococizumab 450 mg + rHuPH20

bococizumab 450 mg + rHuPH20 administered SC to healthy volunteers

BIOLOGICAL

Cohort 4: bococizumab 300 mg + rHuPH20

bococizumab 300 mg + rHuPH20 administered SC to subjects with hypercholesterolemia receiving a statin

Trial Locations (1)

B-1070

Pfizer Clinical Research Unit, Brussels

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Halozyme Therapeutics

INDUSTRY

lead

Pfizer

INDUSTRY