Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)

PHASE1CompletedINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

August 24, 2016

Primary Completion Date

April 30, 2022

Study Completion Date

October 3, 2023

Conditions
GlioblastomaGliosarcomaRecurrent Brain Neoplasm
Interventions
BIOLOGICAL

Anti-LAG-3 Monoclonal Antibody BMS 986016

Given IV

BIOLOGICAL

Anti-PD-1

Given IV

OTHER

Pharmacological Study

Correlative Studies

OTHER

Laboratory Biomarker Analysis

Correlative Studies

BIOLOGICAL

Anti-CD137

Given IV

Trial Locations (11)

10021

Memorial Sloan-Kettering Cancer Center, New York

15232

Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh

19104

Abrams Cancer Center of the University of Pennsylvania, Philadelphia

21231

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

48202

Henry Ford Hospital, Detroit

90095

Jonsson Comprehensive Cancer Center at UCLA, Los Angeles

35294-3410

UAB Comprehensive Cancer Center, Birmingham

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

27157-1096

Wake Forest University Comprehensive Cancer Center, Winston-Salem

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

OTHER