Phase 1/1b Study to Evaluate the Safety and Tolerability of Ciforadenant Alone and in Combination With Atezolizumab in Advanced Cancers

PHASE1CompletedINTERVENTIONAL
Enrollment

502

Participants

Timeline

Start Date

January 31, 2016

Primary Completion Date

June 30, 2021

Study Completion Date

July 31, 2021

Conditions
Renal Cell CancerMetastatic Castration Resistant Prostate Cancer
Interventions
DRUG

Ciforadenant

100 mg orally twice daily for the first 14 days of each 28-day cycle.

DRUG

Ciforadenant

100 mg orally twice daily for 28 days of each 28-day cycle.

DRUG

Ciforadenant

200 mg orally once daily for the first 14 days of each 28-day cycle.

DRUG

Ciforadenant + atezolizumab

Ciforadenant 100 mg orally twice daily in combination with atezolizumab intravenously.

DRUG

Ciforadenant

Start with 150mg orally twice daily for 28-day cycles; then, increase increments by 100mg/day for 6 dose levels.

Trial Locations (20)

3168

Monash Health, Clayton

4029

Royal Brisbane and Women's Hospital, Brisbane

10065

Memorial Sloan Kettering Cancer Center, New York

14263

Roswell Park Cancer Institute, Buffalo

15232

University of Pittsburgh Medical Center Cancer Center, Pittsburgh

21287

Sidney Kimmel Comprehensive Cancer Center - Johns Hopkins University School of Medicine, Baltimore

33136

University of Miami Hospital and Clinics, Miami

44195

Cleveland Clinic, Cleveland

48201

Karmanos Cancer Institute, Detroit

53226

Medical College of Wisconsin, Milwaukee

60612

Rush University Medical Center, Chicago

60637

University of Chicago Medical Center, Chicago

85719

University of Arizona Cancer Center, Tucson

94143

University of California - San Francisco, San Francisco

94305

Stanford Cancer Institute, Stanford

06510

Yale University, New Haven

02114

Massachusetts General Hospital, Boston

T6G 1Z2

Cross Cancer Institute, Edmonton

V5Z 4E6

British Columbia Cancer Agency - Vancouver Centre, Vancouver

K1H 8L6

The Ottawa Hospital Cancer Centre, Ottawa

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Corvus Pharmaceuticals, Inc.

INDUSTRY