Biventricular Pacing in Children With Congenital Heart Disease

NACompletedINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

July 31, 2012

Primary Completion Date

April 30, 2018

Study Completion Date

April 30, 2018

Conditions
Congenital Heart Disease (CHD)
Interventions
DEVICE

Biventricular Pacing (BiVp)

BiVp shortens QRS duration and synchronizes ventricular contraction; thereby decreasing wall stress and increasing CI and BP. In contrast to inotropes, BiVp does not increase myocardial VO2. Resynchronizing myocardial contraction normalizes glucose metabolism, myocardial perfusion and distribution of proteins essential to myocardial contraction and relaxation such as calcium-handling phospholamban. Overall, BiVp improves pump function, increases CI, improves myocardial perfusion and reduces VO2, improving hemodynamics.

Trial Locations (1)

M5G 1X8

The Hospital for Sick Children, Toronto

All Listed Sponsors
lead

The Hospital for Sick Children

OTHER

NCT02644824 - Biventricular Pacing in Children With Congenital Heart Disease | Biotech Hunter | Biotech Hunter