Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor

etoposide 100mg/m2 ivgtt started at the first day of cycle, two weeks a cycle

actinomycin D 500ug ivgtt, started at the first day of cycle, two weeks a cycle

methotrexate 100mg/m2, 200mg/m2, ivgtt, tetrahydrofolic acid （FA) 15mg q12h\*4(24h after methotrexate injection),started at the first day of cycle, two weeks a cycle

vincristine 1mg/m2 started at the 8th day of cycle, two weeks a cycle

cyclophosphamide 600mg/m2, started at the 8th day of cycle, two weeks a cycle

paclitaxel 135mg/m2, started at the first day of cycle, two weeks a cycle

cisplatin 50mg/m2, started at the first day of cycle, two weeks a cycle

carboplatin area under curve (AUC)=4-5, started at the first day of cycle, two weeks a cycle,as a substitute drug for cisplatin