Study to Evaluate Safety and Efficacy of Three Different Dosages of NewGam in Patients With Chronic Inflammatory Demyelinating Poly (Radiculo) Neuropathy

PHASE3CompletedINTERVENTIONAL
Enrollment

142

Participants

Timeline

Start Date

September 27, 2017

Primary Completion Date

September 5, 2019

Study Completion Date

September 5, 2019

Conditions
Chronic Inflammatory Demyelinating Poly(Radiculo)Neuropathy
Interventions
DRUG

NewGam

In the Dose-evaluation Phase, all patients will receive a loading dose of 2.0 g/kg Newgam (administered over two consecutive days), followed by seven infusions of the maintenance dose the patient has been randomized to (0.5, 1.0 or 2.0 g/kg NewGam), also administered over two consecutive days every 3 weeks (±4 days). If a patient is randomized to receive the low or medium NewGam dose, the same volume with the same infusion rate as would have been applied in case the patient would have been randomized to 2.0 g/kg NewGam will be used, thus supplemented with an authorized 0.9% w/v isotonic sodium chloride solution as appropriate and detailed in the following infusion bag split to maintain the blinding

Trial Locations (26)

1204

Jahn Ferenc Del Pesti Korhaz, Budapest

1797

St. Naum Hospital, Sofia

2700

MHAT Puls EOOD, Blagoevgrad

4112

National Medical Academy Of Postgraduate Education Named After P.L. Shupyk, Kyiv

4300

Volyn Regional Clinical Hospital, Lutsk

6725

Szegedi Tudományegyetem ÁOK Neurológiai Klinika, Szeged

21005

Vinnytsia National Medical University, Vinnytsia

37075

University Medical Center Goettigen, Goettigen

69600

Municipal Institution Zaporizhzhya Regional Clinical Hospital, Zaporizhzhya

76008

Ivano Frankivsk National Medical University, Ivano-Frankivsk

125367

Neurology Research Centre, Moscow

192019

National Medical Research Centre of Psychiatry and Neurology n.a. V.M.Bekhterev, Saint Petersburg

194354

City Multifield Hospital #2, Saint Petersburg

420021

Republican Clinical Neurological Centre, Kazan'

500091

Theo Health S.R.L., Brasov

603126

Nizhny Novgorod Regional Clinical Hospital N.A. N.A.Semashko, Nizhny Novgorod

900591

"Spitalul Clinic Judetean de Urgenta Sf.Apostol Andrei Constanta", Constanța

M5G 2C4

Toronto General Hospital, Toronto

H3A2B4

Octapharma Research Site, Montreal

500 03

Outpatient Clinic of Neurology, Hradec Králové

532 03

Regional Hospital Pardubice, Pardubice

140 00

Thomayer Faculty Hospital, Prague

20-954

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie Klinika Neurologii, Lublin

10-561

Wojewodzki Szpital Specjalistyczny W Olsztynie, Olsztyn

50-556

Uniwersytecki Szpital Kliniczny, Wroclaw

022328

Institutul Clinic Fundeni, Bucharest

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Octapharma

INDUSTRY