194
Participants
Start Date
March 9, 2017
Primary Completion Date
October 27, 2021
Study Completion Date
February 2, 2022
Dexamethasone intravitreal implant 0.7 mg
Standard preparation as described for intravitreal injections.
Intravitreal Methotrexate 400 µg
Intravitreal Methotrexate 400 µg injection procedures should be carried out under controlled aseptic conditions which include the use of sterile gloves and a sterile eyelid speculum (or equivalent). Adequate anesthesia and a broad-spectrum microbicide such as betadine, applied to the periocular skin, eyelid and ocular surface are required prior to the injection.
Intravitreal Ranibizumab 0.5 mg
Intravitreal Ranibizumab 0.5 mg injection procedures should be carried out under controlled aseptic conditions which include the use of sterile gloves and a sterile eyelid speculum (or equivalent). Adequate anesthesia and a broad-spectrum microbicide such as betadine, applied to the periocular skin, eyelid and ocular surface are required prior to the injection.
University of Pittsburgh Medical Center, Pittsburgh
Scheie Eye Institute, University of Pennsylvania, Philadelphia
MidAtlanitc Retina, Wills Eye Hospital, Philadelphia
Johns Hopkins University, Baltimore
Duke Eye Center, Duke University, Durham
Emory University, Atlanta
Anne Bates Leach Eye Hospital, University of Miami Miller School of Medicine, Miami
Vanderbilt, Nashville
University of Louisville, Louisville
Kellogg Eye Center, University of Michigan, Ann Arbor
University of Iowa, Iowa City
Northwestern University, Chicago
Rush University Medical Center, Chicago
Retinal Consultants of Houston, Houston
John A. Moran Eye Center, University of Utah, Salt Lake City
Jules Stein Eye Institute, UCLA, Los Angeles
University of California, San Francisco, San Francisco
LV Prasad Eye Institute - Hyderabad, Hyderabad
Massachusetts Eye and Ear Infirmary, Boston
Ophthalmic Consultants of Boston, Boston
Royal Victorian Eye and Ear Hospital, East Melbourne
LV Prasad Eye Institute - Bhubaneswar, Bhubaneswar
Medical and Vision Research Foundation, Chennai
Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh
McGill University, Montreal
University Hospitals Bristol NHS Foundation Trust, Bristol
Cambridge University Hospitals NHS Foundation Trust, Cambridge
University Hospitals of Leicester NHS Trust, Leicester
Liverpool University Hospitals NHS Foundation Trust, Liverpool
Moorfields Eye Hospital NHS Foundation Trust, London
Manchester University NHS Foundation Trust, Manchester
University Hospitals Birmingham NHS Foundation Trust, Birmingham
Moorfields Eye Hospital, London
Lead Sponsor
National Eye Institute (NEI)
NIH
JHSPH Center for Clinical Trials
OTHER