A Study to Assess the Feasibility of Romidepsin Combined With Brentuximab Vedotin in Cutaneous T-cell Lymphoma

PHASE1CompletedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

February 22, 2017

Primary Completion Date

August 8, 2022

Study Completion Date

January 31, 2024

Conditions
Cutaneous T-cell Lymphoma (CTCL)
Interventions
DRUG

Romidepsin

Romidepsin at the dosage 10mg/m2 or 14mg/m2 will be given ONCE 14 days prior to cycle one and then on days 1,8,15 in each cycle. Each cycle is 28 days and treatment will continue up to 16 cycles

DRUG

Brentuximab vedotin

Brentuximab vedotin at the dosage 0.9mg/kg or 1.2 mg/kg will be given on days 1 and 15 in each cycle. Each cycle is 28 days and treatment will continue up to 16 cycles

Trial Locations (2)

19104

University of Pennsylvania, Perelman Center, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Seagen Inc.

INDUSTRY

collaborator

Celgene Corporation

INDUSTRY

lead

Fox Chase Cancer Center

OTHER

NCT02616965 - A Study to Assess the Feasibility of Romidepsin Combined With Brentuximab Vedotin in Cutaneous T-cell Lymphoma | Biotech Hunter | Biotech Hunter