A Phase 1 Study To Evaluate Escalating Doses Of A Vaccine-Based Immunotherapy Regimen For Prostate Cancer (PrCa VBIR)

PHASE1TerminatedINTERVENTIONAL
Enrollment

91

Participants

Timeline

Start Date

December 30, 2015

Primary Completion Date

February 23, 2021

Study Completion Date

February 23, 2021

Conditions
Prostatic Neoplasms
Interventions
BIOLOGICAL

PF-06755992

PF-06755992 will be administered on Day 1 of Cycles 1 and 2.

BIOLOGICAL

PF-06755990

PF-06755990 will be administered using a device on Day 29, 57 and 85 of each cycle.

DEVICE

TDS-IM Electroporation Device

TDS-IM electroporation device and associated supplies will be used for PF-06755990 administration

BIOLOGICAL

Tremelimumab

PF-06753388 will be administered every 28 days.

BIOLOGICAL

PF-06801591

PF-06801591 will be administered every 28 days.

BIOLOGICAL

PF-06753512

Combination of adenovirus (AdC68) + plasmid DNA (pDNA) + tremelimumab

Trial Locations (19)

10022

Memorial Sloan-Kettering Cancer Center 53rd Street, New York

10065

Memorial Sloan Kettering Cancer Center, New York

Memorial Sloan-Kettering Cancer Center, Sidney Kimmel Center, New York

11042

Northwell Health, Lake Success

15232

UPMC Hillman Cancer Center, Pittsburgh

20892

National Institutes of Health Clinical Center, Bethesda

27710

Duke University Medical Center, Durham

68130

GU Research Network, Omaha

85719

Banner-University Medical Center Tucson, Tucson

The University of Arizona Cancer Center-North Campus, Tucson

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

98109

Seattle Cancer Care Alliance, Seattle

98195

University of Washington Medical Center, Seattle

06510

Smilow Cancer Hospital at Yale-New Haven, New Haven

06511

Smilow Cancer Hospital Phase 1 Unit, New Haven

07960

Garden State Urology, Morristown

Morristown Medical Center, Morristown

07866

Garden State Urology, Rockaway

07981

Garden State Urology, Whippany

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02616185 - A Phase 1 Study To Evaluate Escalating Doses Of A Vaccine-Based Immunotherapy Regimen For Prostate Cancer (PrCa VBIR) | Biotech Hunter | Biotech Hunter