Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM)

PHASE2CompletedINTERVENTIONAL
Enrollment

248

Participants

Timeline

Start Date

December 3, 2015

Primary Completion Date

May 31, 2017

Study Completion Date

September 6, 2019

Conditions
Mesothelioma
Interventions
DRUG

Anetumab ravtansine (BAY94-9343)

Starting dose: 6.5 mg/kg administered as IV infusion over 1 h every 3 weeks until disease progression or treatment withdrawal for any reason. Dose reductions are permitted.

DRUG

Vinorelbine

Starting dose: 30mg/m\^2 administered as an IV infusion over 6 to 10 min every week until disease progression or treatment withdrawal for any reason. Dose reductions are permitted per standard practise.

Trial Locations (75)

1200

Bruxelles - Brussel

2065

St Leonards

2650

Edegem

3000

Leuven

3122

Richmond

4000

Liège

4102

Woolloogabba

5043

Adelaide

6009

Nedlands

9000

Ghent

9100

Sint-Niklaas

10016

New York

10043

Turin

13915

Marseille

14076

Caen

15006

A Coruña

20089

Milan

20133

Milan

20520

Turku

20814

Bethesda

20900

Monza Brianza

24125

Bergamo

26480

Eskişehir

27710

Durham

28041

Madrid

29010

Málaga

33076

Bordeaux

33081

Pordenone

33612

Tampa

34899

Istanbul

44195

Cleveland

44280

Malatya

53100

Siena

55905

Rochester

59037

Lille

60612

Chicago

60637

Chicago

65130

Vaasa

69495

Pierre-Bénite

70121

New Orleans

75018

Paris

75020

Paris

75251

Dallas

77030

Houston

80045

Aurora

620036

Yekaterinburg

644013

Omsk

92093-1503

La Jolla

06360

Norwich

14263-0001

Buffalo

T2N 4N2

Calgary

L8V 5C2

Hamilton

N6A 4L6

London

M5G 2M9

Toronto

00290

Helsinki

1066 CX

Amsterdam

3015 CE

Rotterdam

80-952

Gdansk

31-202

Krakow

31-501

Krakow

70-891

Szczecin

05505

Seoul

06351

Seoul

03010

Alicante

08035

Barcelona

01330

Adana

06100

Ankara

06200

Yenimahalle

PL6 8DH

Plymouth

ME16 9QQ

Maidstone

LE1 5WW

Leicester

G12 0YN

Glasgow

SE1 9RT

London

M23 9LT

Manchester

NE7 7DN

Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

ImmunoGen and MorphoSys

UNKNOWN

lead

Bayer

INDUSTRY

NCT02610140 - Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM) | Biotech Hunter | Biotech Hunter