1,659
Participants
Start Date
December 14, 2015
Primary Completion Date
February 28, 2017
Study Completion Date
April 7, 2017
Aprocitentan 5 mg
One capsule of 5 mg aprocitentan, orally, once daily in the morning for 8 weeks, along with placebo capsule matching lisinopril.
Aprocitentan 10 mg
Two capsules of 5 mg aprocitentan, orally, once daily in the morning for 8 weeks.
Aprocitentan 25 mg
One capsule of 25 mg aprocitentan, orally, once daily in the morning for 8 weeks, along with placebo capsule matching lisinopril.
Aprocitentan 50 mg
One capsule of 50 mg aprocitentan, orally, once daily in the morning for 8 weeks, along with placebo capsule matching lisinopril.
Lisinopril 20 mg
One capsule of 20 mg lisinopril, orally, once daily in the morning for 8 weeks, along with placebo capsule matching aprocitentan
Placebo
One capsule each of placebo matching aprocitentan and placebo matching lisinopril orally, once daily in the morning for 8 weeks.
Internal Med Department A, Ziv Medical Center, Safed
Rochester Clinical Research Inc., Rochester
Suburban Research Center, Media
Detweiler Family Medicine and Associates PC, Lansdale
Alfieri Cardiology, Wilmington
National Clinical Research Inc, Richmond
Health Research of Hampton Roads, Newport News
Peters Medical Research, High Point
Pharmquest LLC, Greensboro
Metrolina Internal Medicine/Internal Medicine Research, Charlotte
Degarmo Institute of Medical Research, Greer
Southeast Regional Research Group, Savannah
Avail Clinical Research LLC, DeLand
AGA Clinical Trials, Hialeah
LCC Medical Research Institute, Miami
Allied Biomedical Research Institute, INC, Miami
Alan Graff, MD, PA, Fort Lauderdale
ACRC - Cardiology, Atlantis
Canvas Clinical Research, LLC, Lake Worth
Innovative Research of West Florida INC, Clearwater
Gulfcoast Clinical Research Center, Fort Myers
Appalachian Cardiovascular Associates, Fort Payne
Volunteer Research Group, Knoxville
Aventiv Research Inc., Dublin
Aventiv Research Inc., Columbus
Hypertension And Nephrology Department, Meir Medical Center, Kefar Sava
Sterling Research Group Ltd., Cincinnati
Dayton Clinical Research, Dayton
Community Clin Res CTR, Anderson
Midwest Institute for Clinical Research, Indianapolis
Clinsite LLC, Ann Arbor
The Hyper Unit, Edith Wolfson Medical Center, Holon
Lillestol Research LLC, Fargo
Primecare Research Associates, LLC, Florissant
Heartland Research Associated LLC, Newton
Heartland Research Associates LLC, Wichita
Heartland Research Associates LLC, Wichita
Best Clinical Trials LLC, New Orleans
New Orleans Center for Clinical Research - Nola, New Orleans
Avant Research Associates, LLC, Crowley
Oklahoma City Clinic - Edmond / Radiant Research Inc, Edmond
Clinical Research Advantage, Inc. / Oklahoma City Clinic - Midwest City, Midwest City
Trinity Hypertension & Metabolic Research Institute, Carrollton
Family Medicine Associates of Texas - ACRC Trials, Carrollton
Clinical Investigations of Texas, Plano
TR - Global Medical Research, DeSoto
Clinical Research Unit Kaplan Medical Center, Rehovot
Ventavia Research Group, LLC, Fort Worth
Avant Research Associates LLC, Port Arthur
Radiant Research Inc, San Antonio
Bandera Family Health Care, San Antonio
Cardiology Department Barzilai, Ashkelon
Coastal Bend Clinical Research, Corpus Christi
Texas Diabetes & Endocrinology, Round Rock
Tekton Research Inc, Austin
Texas Diabetes & Endocrinology, Austin
Soroka University Hospital - Hypertension Unit, Beersheba
Wasatch Clinical Research LLC, Salt Lake City
Radiant Research Inc, Chandler
Warner Family Practice / Radiant Research Inc, Chandler
Phoenix Medical Research Institute LLC, Peoria
Advanced Arizona Clinical Research, Tucson
Noble Clinical Research LLC, Tucson
Desert Sun Clinical Research LLc, Tucson
Clinical Research Advantage, Inc. / Diagnostic Center Of Medicine - Durango, Las Vegas
Entertainment Medical Group Inc, Los Angeles
Long Beach Center for Clinical Research, Long Beach
Hypertension Treatment Center, Internal Dep, Hadassah, Jerusalem
Empire Clinical Research, Upland
Artemis institute for Clinical Research, San Diego
Memorial Research Medical Clinic / Orange County Research Center, Tustin
Advanced Research Center Inc, Anaheim
John Muir Physician Network Clinical Research Center, Concord
Med Center, Carmichael
Clinical Trials Research, Lincoln
Willamette Valley Clinical Studies, Eugene
Northwest Clinical Research Center, Bellevue
Clinical Research Consulting LLC, Milford
Chase Medical Research LLC, Waterbury
Premier Research, Trenton
Wake Research Associates, Raleigh
Manna Research - Vancouver, Vancouver
Canadian Phase Onwards Inc, Toronto
Manna Research - Toronto, Toronto
Manna Research - Levis, Lévis
Diex Recherche Montreal Inc, Montreal
Manna Research - Pointe Claire, Pointe-Claire
Diex Reserach Sherbrooke Inc, Sherbrooke
Advanced Medical Concepts, PSC, Cidra
Research & Cardiovascular Corp., Ponce
Lead Sponsor
Idorsia Pharmaceuticals Ltd.
INDUSTRY