501
Participants
Start Date
January 31, 2016
Primary Completion Date
June 7, 2017
Study Completion Date
June 7, 2017
ALN-PCSSC
ALN-PCSSC is a small interfering ribonucleic acid (RNA) that inhibits PCSK9 synthesis and is given as SC injections
Normal Saline
Saline (sterile, normal, 0.9%) solution given as SC injections
Mount Sinai Icahn School of Medicine, New York
Medical University Berlin, Berlin
University Heart Center Hamburg, Hamburg
National Clinical Research, Inc., Richmond
Jacksonville Center for Clinical Research, Jacksonville
Wellmont CVA Heart Institute, Greeneville
Metabolic And Atherosclerosis Research Center, Cincinnati
Sterling Research Group, Cincinnati
Medical Center Essen, Essen
Midwest Institute For Clinical Research, Indianapolis
University Hospital Frankfurt, Frankfurt
Medical University Hospital Heidelberg, Internal medicine III, Heidelberg
Amarillo Heart Clinical Research Institute, Inc., Amarillo
Technical University Munich, German Heart Center, Munich
St. Paul's Hospital, Vancouver
St. Boniface Hospital, Winnipeg
Eastern Regional Health Authority, Patient Research Centre, St. John's
Brampton Research Associates, Brampton
Lawson Health Research Institute, London
St. Michael's Hospital, Toronto
ECOGENE-21 Clinical Trials Center, Chicoutimi
Clinic Sante Cardio MC, Montreal
Institut de Recherches Cliniques de Montreal, Montreal
Université Laval Quebec, Québec
Clinique des maladies lipidique Quebec, Québec
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS), Sherbrooke
Amsterdam Medical Center, Amsterdam
Deventer Ziekenhuis, Deventer
Andromed Eindhoven, Eindhoven
Admiraal de Ruyter Hospital, Cardiology, Goes
Bethesda Diabetes Research Center, Hoogeveen
Medisch Centrum Gorecht, Hoogezand
VOC Hoorn, Hoorn
Leids Universitair Medisch Centrum (LUMC), Leiden
Andromed Rotterdam, Rotterdam
Haga Hospital, The Hague
Diakonessenhuis, Vascular Policlinic, Utrecht
UMC Utrecht, Utrecht
VieCurie Venlo, Cardiology, Venlo
Albert Schweitzer Hospital, Cardiology, Zwijndrecht
Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham
Edinburgh Royal Infirmary, Edinburgh
The Royal Devon and Exeter NHS Trust, Exeter
Fowey River Practice, Fowey
Buckinghamshire NHS Trust, High Wycombe
Oak Tree Surgery, Liskeard
Royal Free Hospital, London
Central Manchester University Hospital NHS Foundation Trust, Manchester
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne
The Alverton Practice, Penzance
Knowle House Surgery, Plymouth
Brannel Surgery, St Austell
Rame Medical Ltd (Rame Research), Torpoint
Worcestershire Acute NHS Trust, Worcester
Lead Sponsor
The Medicines Company
INDUSTRY