NCT02595931View on ClinicalTrials.gov

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

July 22, 2016

Primary Completion Date

March 7, 2023

Study Completion Date

March 6, 2026

Conditions
Metastatic Colorectal CarcinomaMetastatic Lung Small Cell CarcinomaMetastatic Malignant Solid NeoplasmMetastatic Pancreatic CarcinomaRefractory Colorectal CarcinomaRefractory Lung Small Cell CarcinomaRefractory Malignant Solid NeoplasmRefractory Pancreatic CarcinomaStage III Colorectal Cancer AJCC v8Stage III Lung Cancer AJCC v8Stage III Pancreatic Cancer AJCC v8Stage IV Colorectal Cancer AJCC v8Stage IV Lung Cancer AJCC v8Stage IV Pancreatic Cancer AJCC v8Unresectable Colorectal CarcinomaUnresectable Lung Small Cell CarcinomaUnresectable Malignant Solid NeoplasmUnresectable Pancreatic Carcinoma
Interventions
DRUG

Berzosertib

Given IV

PROCEDURE

Biopsy Specimen

Undergo biopsy

PROCEDURE

Biospecimen Collection

Correlative studies

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Irinotecan Hydrochloride

Given IV

Trial Locations (23)

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

32610

University of Florida Health Science Center - Gainesville, Gainesville

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

48201

Wayne State University/Karmanos Cancer Institute, Detroit

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91105

Keck Medical Center of USC Pasadena, Pasadena

94115

UCSF Medical Center-Mount Zion, San Francisco

94304

Stanford Cancer Institute Palo Alto, Palo Alto

95817

University of California Davis Comprehensive Cancer Center, Sacramento

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Brigham and Women's Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH