NCT02595879 - Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 18, 2019

Primary Completion Date

June 4, 2023

Study Completion Date

April 29, 2026

Conditions

Advanced Cervical AdenocarcinomaAdvanced Cervical Adenosquamous CarcinomaAdvanced Cervical Squamous Cell CarcinomaAdvanced Vaginal AdenocarcinomaAdvanced Vaginal Adenosquamous CarcinomaAdvanced Vaginal Squamous Cell CarcinomaStage IB2 Cervical Cancer AJCC v6 and v7Stage II Cervical Cancer AJCC v7Stage II Vaginal Cancer AJCC v6 and v7Stage III Vaginal Cancer AJCC v6 and v7Stage IIIB Cervical Cancer AJCC v6 and v7Stage IVA Cervical Cancer AJCC v6 and v7Stage IVA Vaginal Cancer AJCC v6 and v7

Interventions

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

RADIATION

Brachytherapy

Undergo LDR brachytherapy

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo FDG-PET/CT

RADIATION

External Beam Radiation Therapy

Undergo pelvic EBRT

OTHER

Fludeoxyglucose F-18

Undergo FDG-PET/CT

RADIATION

High-Dose Rate Brachytherapy

Undergo HDR brachytherapy

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Pharmacological Study

Correlative studies

PROCEDURE

Positron Emission Tomography

Undergo FDG-PET/CT

DRUG

Triapine

Given IV and PO

Trial Locations (17)

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

35233

University of Alabama at Birmingham Cancer Center, Birmingham

40536

University of Kentucky/Markey Cancer Center, Lexington

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48334

Weisberg Cancer Treatment Center, Farmington Hills

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Clinical Research Center, Fairway

University of Kansas Hospital-Westwood Cancer Center, Westwood

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

73104

University of Oklahoma Health Sciences Center, Oklahoma City

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91105

Keck Medical Center of USC Pasadena, Pasadena

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH