Study to Assess the Safety and Preliminary Efficacy of AZD0156 at Increasing Doses Alone or in Combination With Other Anti-cancer Treatment in Patients With Advanced Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

November 10, 2015

Primary Completion Date

September 13, 2019

Study Completion Date

July 26, 2022

Conditions
Advanced Solid Tumours
Interventions
DRUG

AZD0156

All patients will receive AZD0156 as a monotherapy or in combination to assess safety and tolerability.

DRUG

Olaparib

Module 1 combination with olaparib

DRUG

irinotecan

Module 2 combination with irinotecan/FOLFIRI

DRUG

Fluorouracil

Module 2 combination with irinotecan/FOLFIRI

DRUG

Folinic Acid

Module 2 combination with irinotecan/FOLFIRI

Trial Locations (5)

10033

Research Site, New York

80045

Research Site, Aurora

03080

Research Site, Seoul

08035

Research Site, Barcelona

M20 4BX

Research Site, Manchester

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Syneos Health

OTHER

lead

AstraZeneca

INDUSTRY