Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101)

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

December 18, 2015

Primary Completion Date

February 2, 2021

Study Completion Date

July 13, 2022

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Avelumab

Administered by IV once every two weeks in doses of either 5 mg/kg or 10 mg/kg

DRUG

PF-06463922

Tablets taken orally once every day in doses of either 100mg, 75mg, or 50mg.

DRUG

Crizotinib

Capsules. Taken orally once or twice every day in doses of either 200mg or 250mg.

Trial Locations (20)

2050

Chris O'Brien Lifehouse, Camperdown

3000

Peter MacCallum Cancer Centre, Melbourne

3050

Royal Melbourne Hospital, Parkville

4032

The Prince Charles Hospital, Chermside

10408

National Cancer Center, Goyang-si

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital, Atlanta

The Emory Clinic, Atlanta

Winship Cancer Institute of Emory University, Atlanta

37203

Tennessee Oncology, PLLC, Nashville

02114-2696

Massachusetts General Hospital, Boston

02114

Ophthalmic Consultants of Boston Inc (OCB), Boston

464-8681

Aichi cancer center central hospital, Nagoya

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

135-8550

The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08916

Institut Catala d'Oncologia de Badalona, Badalona

08023

Hospital Quiron Barcelona, Barcelona

08035

Hospital Universitari de la Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02584634 - Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101) | Biotech Hunter | Biotech Hunter