A Phase III Trial Evaluating Chemotherapy and Immunotherapy for Advanced Nasopharyngeal Carcinoma (NPC) Patients

PHASE3CompletedINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

February 28, 2022

Study Completion Date

February 28, 2022

Conditions
Nasopharyngeal Carcinoma
Interventions
BIOLOGICAL

autologous EBV specific Cytotoxic T cells

The CTL line will be prepared by co-cultivation of the irradiated EBV-LCL with patient PBMC. A proportion of peripheral blood will be used to generate EBV specific CTLs.

DRUG

combination IV gemcitabine and IV carboplatin (AUC2)

4 cycles for Arm A and 6 cycles for Arm B

Trial Locations (30)

75204

Baylor Scott & White, Dallas

77030

Baylor College of Medicine, Houston

91010

City of Hope National Medical Center, Duarte

94143

UCSF HDF Comprehensive Cancer Center, San Francisco

94305

Stanford Cancer Center, Stanford

95817

University of California Davis Health, Sacramento

02215

Massachusetts General Hospital, Boston

Unknown

Site MY-03, George Town

Site MY-06, George Town

Site MY-07, Johor Bahru

Site MY-01, Kuala Lumpur

Site MY-04, Kuala Lumpur

Site MY-05, Kuala Lumpur

Site MY-08, Kuala Lumpur

Site SG-11, Singapore

Site SG-12, Singapore

Changhua Christian Hospital, Changhua

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

China Medical University Hospital, Taichung

Taichung Veterans General Hospital, Taichung

National Taiwan University Hospital, Taipei

Taipei Veterans General Hospital, Taipei

Linkou Chang Gung Memorial Hospital, Taoyuan District

Site TH-42, Bangkok

Site TH-43, Bangkok

Site TH-41, Chiang Mai

Site TH-44, Khon Kaen

Site TH-47, Lopburi

Site TH-45, Ubon Ratchathani

Site TH-46, Udon Thani

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Tessa Therapeutics

INDUSTRY

NCT02578641 - A Phase III Trial Evaluating Chemotherapy and Immunotherapy for Advanced Nasopharyngeal Carcinoma (NPC) Patients | Biotech Hunter | Biotech Hunter