Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV)

PHASE2TerminatedINTERVENTIONAL
Enrollment

79

Participants

Timeline

Start Date

December 31, 2015

Primary Completion Date

December 31, 2016

Study Completion Date

December 31, 2016

Conditions
Hepatitis BHepatitis D
Interventions
DRUG

ARC-520

ARC-520 will be administered intravenously concomitantly with 0.9% normal saline using an infusion rate of 0.4 mL/min (24 mL/hour) for study treatment and 200 mL/hr for saline.

DRUG

entecavir

0.5 mg once daily; oral

BIOLOGICAL

pegylated interferon alpha 2a

180 mcg; subcutaneous injection once weekly

DRUG

tenofovir disoproxil

300 mg once daily; oral

DRUG

antihistamine

All participants will be pre-treated with an oral antihistamine selected by the investigator from the list of approved antihistamines that is available in that country. Acceptable antihistamines are: diphenhydramine 50 mg p.o., chlorpheniramine 8 mg p.o., hydroxyzine 50 mg p.o., or cetirizine 10 mg p.o.

Trial Locations (33)

500

Changhua Christian Hospital, Changhua

640

National Taiwan University Hospital, Yun-Lin Branch, Douliu

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1010

Auckland Clinical Studies, Auckland

1431

UMHAT St. Ivan Rilski EAD, Clinic of Gastroenterology, Sofia

1463

Diagnostic and Consultative Center - Focus 5 - Outpatient Medical Center, EOOD, Sofia

2010

St. Vincent's Hospital Sydney, Darlinghurst

2025

Middlemore Clinical Trials, Middlemore Hospital, Papatoetoe

2050

Royal Prince Alfred Hospital, Camperdown

2139

Concord Repatriation General Hospital, Gastroenterology & Liver Services, Concord

2145

Westmead Hospital, Westmead

3052

Royal Melbourne Hospital, Parkville

3065

St. Vincent's Hospital Melbourne, Fitzroy

3080

Seoul National University Hospital, Seoul

3168

Monash Health Clayton Campus, Clayton

5000

Royal Adelaide Hospital, Adelaide

5800

MHAT St. Pantaleimon OOD, Department of Gastroenterology, Pleven

6009

Linear Clinical Research Ltd., Nedlands

6273

Gangnam Severance Hospital, Yonsei University Health System, Seoul

9020

Diagnostic and Consultative Center Mladost-M Varna, Varna

10330

King Chulalongkorn Memorial Hospital, Bangkok

10400

Hospital of Tropical Diseases, Bangkok

Phramongkutklao Hospital, Division of Digestive and Liver Disease, Bangkok

12120

Thammasat University Hospital, Gastroenterology Unit, Pathum Thani

40002

Khon Kaen University, Khon Kaen

41944

Kyungpook National University Hospital, Daegu

49241

Pusan National University Hospital, Busan

50200

Maharaj Nakhon Chiang Mai Hospital, Gastroenterology Division, Chiang Mai

Unknown

Queen Mary Hospital, Department of Medicine, Hong Kong

Dunedin Hospital, Gastroenterology Research Unit, Dunedin

Inje University Busan Paik Hospital, Busan

Severance Hospital, Yonsei University Health System, Seoul

MD-2004

IMSP Spitalul Clinic de Boli Infectioase, Toma Ciorba, Chisinau

Sponsors
All Listed Sponsors
lead

Arrowhead Pharmaceuticals

INDUSTRY