Study of Methylnaltrexone in Opioid-Induced Constipation Patients

PHASE2/PHASE3UnknownINTERVENTIONAL
Enrollment

198

Participants

Timeline

Start Date

April 30, 2015

Primary Completion Date

December 31, 2016

Study Completion Date

April 30, 2017

Conditions
Opioid-induced Constipation
Interventions
DRUG

Methylnaltrexone (MNTX)

MNTX nearly 0.15mg/kg administered every other day for 2 weeks. Baseline laxatives and rescue laxative ( enemas/suppositories ) were allowed, but could not be administered within 4 hours of the study drug.

DRUG

Placebo

Placebo administered every other day for 2 weeks. Baseline laxatives and rescue laxative ( enemas/suppositories ) were allowed, but could not be administered within 4 hours of the study drug.

Trial Locations (12)

150081

RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200092

RECRUITING

Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

202150

RECRUITING

Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine Chongming Branch, Shanghai

221000

RECRUITING

The Affiliated Hospital of Xuzhou Medical College, Xuzhou

230032

RECRUITING

The Second Hospital of Anhui Medical University, Hefei

276000

RECRUITING

Linyi Cancer Hospital, Linyi

330029

RECRUITING

Jiangxi Cancer Hospital, Nanchang

350009

RECRUITING

Fujian Provincial cancer Hospital, Fuzhou

430071

RECRUITING

Zhongnan Hospital of Wuhan University, Wuhan

451100

RECRUITING

Henan Provincial Cancer Hospital, Zhengzhou

650118

RECRUITING

Tumor Hospital of Yunnan Province The Third Affiliated Hospital of Kunming Medical University, Kunming

710038

RECRUITING

Tangdu Hospital, Xian

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY