48
Participants
Start Date
January 31, 2012
Primary Completion Date
February 28, 2014
Study Completion Date
February 28, 2014
Ketamine Hydrochloride
50 mg/ml, IV (in the vein) during surgery operation, followed by IV ketamine hydrocloride perfusion 2mcg/Kg/min before and until 72 hours after operation Number of Cycles: until progression or unacceptable toxicity develops.
Placebo
50 mg/ml, IV (in the vein) during surgery operation, followed by IV placebo perfusion 2mcg/Kg/min before and until 72 hours after operation
Remifentanil
at doses of 0.3 mcg / kg / min during and until the end of the surgical operation
Morphine hydrochloride
at the dose of 150 mcg / kg, 60 minutes before the extubation procedure and until 72 hours after operation by intravenous infusion
Hospital Sant Joan de Déu, Esplugues de Llobregat
Instituto de Salud Carlos III
OTHER_GOV
Fundació Sant Joan de Déu
OTHER