A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

480

Participants

Timeline

Start Date

November 30, 2015

Primary Completion Date

April 30, 2020

Study Completion Date

April 30, 2020

Conditions
Alzheimers Disease
Interventions
BIOLOGICAL

CAD106 Immunotherapy

Participants will be given i.m. injections at Weeks 1, 7, 13 and quarterly i.m. injections (every 13 weeks) thereafter, until the last injection 3 month prior to completion of the Treatment Epoch.

OTHER

Placebo to CAD106

Participants will be given i.m. injections at Weeks 1, 7, 13 and quarterly i.m. injections (every 13 weeks) thereafter, until the last injection 3 month prior to completion of the Treatment Epoch.

DRUG

CNP520

CNP520 50 mg capsule p.o. for the duration of the Treatment Epoch.

OTHER

Placebo to CNP520

Placebo to CNP520 p.o. for the duration of the Treatment Epoch

OTHER

Alum

Alum was mixed with reconstituted CAD106 as adjuvant therapy to maximize the effectiveness of CAD106

Trial Locations (129)

2010

Novartis Investigative Site, Darlinghurst

3000

Novartis Investigative Site, Leuven

3081

Novartis Investigative Site, Heidelberg Heights

4002

Novartis Investigative Site, Basel

6009

Novartis Investigative Site, Nedlands

9000

Novartis Investigative Site, Ghent

10016

NYU Langone Medical Center, New York

10962

The Nathan S. Kline Institute, Orangeburg

12110

The Memory Center of Northeastern New York, Latham

13353

Novartis Investigative Site, Berlin

14620

University of Rochester Medical Center, Rochester

19046

The Clinical Trial Center, LLC, Jenkintown

19090

Abington Neurological Associates, Willow Grove

19104

Novartis Investigative Site, Philadelphia

20009

Novartis Investigative Site, Donostia / San Sebastian

20057

Georgetown University, Washington D.C.

20059

Novartis Investigative Site, Washington D.C.

20520

Novartis Investigative Site, Turku

24105

Novartis Investigative Site, Kiel

27410

Triad Clinical Trials, LLC, Greensboro

27705

Duke University Medical center, Durham

28223

Novartis Investigative Site, Pozuelo de Alarcón

28270

Alzheimer's Memory Center, Charlotte

29401

Roper St. Francis - CBRI, Charleston

30033

NeuroStudies, Decatur

30322

Novartis Investigative Site, Atlanta

31909

Medical Research & Health Education Foundation, Inc., Columbus

32127

Progressive Medical Research, Port Orange

32224

Novartis Investigative Site, Jacksonville

32751

Meridien Research, Maitland

32806

Novartis Investigative Site, Orlando

32812

Compass Research, Orlando

32952

Merritt Island Medical Research, Merritt Island

33136

University of Miami, Miami

33140

Mount Sinai Medical Center - The Wien Center, Miami Beach

33431

Florida Atlantic University, Clinical Translational Research Unit, Boca Raton

33445

Brain Matters Research, Delray Beach

33613

USF Health Byrd Alzheimer's Institute, Tampa

37075

Novartis Investigative Site, Göttingen

37212

Novartis Investigative Site, Nashville

37920

Novartis Investigative Site, Knoxville

38119

CNS Healthcare, Memphis

40504

Sanders Brown Center on Aging, University of Kentucky, Lexington

43210

Novartis Investigative Site, Columbus

44122

University Hospitals Cleveland Medical Center / Case Western Reserve University, Beachwood

45459

Novartis Investigative Site, Centerville

46202

Indiana University, Indianapolis

48149

Novartis Investigative Site, Münster

49008

Novartis Investigative Site, Kalamazoo

50937

Novartis Investigative Site, Cologne

53226

The Medical College of WI, Milwaukee

55130

Novartis Investigative Site, Saint Paul

57076

Novartis Investigative Site, Siegen

60612

Rush University Medical Center, Chicago

60640

Great Lakes Clinical Trials, Chicago

63104

Novartis Investigative Site, St Louis

66205

University of Kansas Alzheimer's Disease Center, Fairway

67214

Via Christi Research, Wichita

68159

Novartis Investigative Site, Mannheim

71032

Novartis Investigative Site, Böblingen

73103

IPS Research Company, Oklahoma City

73112

Novartis Investigative Site, Oklahoma City

75231

Kerwin Research Center & Memory Care, Dallas

77030

Houston Methodist Hospital, Houston

77054

University of Texas Health Science Center, Houston, Houston

77074

Clinical Trial Network, Houston

78757

Senior Adults Specialty Research, Austin

81621

Novartis Investigative Site, Basalt

83642

Advanced Clinical Research, Meridian

85006

Banner Alzheimer's Institute, Phoenix

Novartis Investigative Site, Phoenix

85259

Novartis Investigative Site, Scottsdale

85351

Banner Sun City Research Institute, Sun City

89106

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas

90033

University of Southern California Keck School of Medicine Alzheimer Disease Research Center, Los Angeles

91316

California Neuroscience Research Medical Group, Inc., Sherman Oaks

92103

Novartis Investigative Site, San Diego

92591

Novartis Investigative Site, Temecula

92614

Irvine Center for Clinical Research, Irvine

92626

ATP Clinical Research, Inc., Costa Mesa

92705

Syrentis Clinical Research, Santa Ana

93173

Novartis Investigative Site, Wenzenbach

94304

Novartis Investigative Site, Palo Alto

95445

Novartis Investigative Site, Bayreuth

95472

Novartis Investigative Site, Sebastopol

97210

Memory Health Center at Summit Research Network, Portland

98405

Universal Research Group, Tacoma

06510

Yale University Alzheimer's Disease Research Unit, New Haven

06905

New England Institute for Clinical Research, Stamford

33462-6608

JEM Research Institute, Atlantis

04401

Novartis Investigative Site, Bangor

02115

Novartis Investigative Site, Boston

02118

Novartis Investigative Site, Boston

68198-7680

Memory Disorders Program, Department of Neurological Sciences, University of Nebraska Medical Center, Omaha

07724

Memory Enhancement Center, Eatontown

02906

Butler Hospital Memory and Aging Program, Providence

05201

The Memory Clinic, Bennington

V1Y1Z9

Okanagan Clinical Trials, Kelowna

B4N 4K9

Novartis Investigative Site, Kentville

B3S 1M7

Novartis Investigative Site, Halifax

N6C 0A7

Novartis Investigative Site, London

M3B 2S7

Toronto Memory Program, Toronto

M4G 3E8

The Centre for Memory and Aging, Toronto

M4N 3M5

Novartis Investigative Site, Toronto

J8T 8J1

Novartis Investigative Site, Gatineau

G1J 1Z4

Novartis Investigative Site, Québec

J1H 5N4

Novartis Investigative Site, Sherbrooke

J1J 2G2

Novartis Investigative Site, Sherbrooke

06120

Novartis Investigative Site, Halle

04107

Novartis Investigative Site, Leipzig

1081 GN

Novartis Investigative Site, Amsterdam

08221

Novartis Investigative Site, Terrassa

08005

Novartis Investigative Site, Barcelona

08014

Novartis Investigative Site, Barcelona

BS10 5NB

Novartis Investigative Site, Westbruy on Trym

EX2 5DW

Novartis Investigative Site, Exeter

PL6 8BT

Novartis Investigative Site, Plymouth

GU27YD

Novartis Investigative Site, Guildford

BA1 3NG

Novartis Investigative Site, Avon

B16 8QQ

Novartis Investigative Site, Birmingham

DD1 9SY

Novartis Investigative Site, Dundee

G20 0XA

Novartis Investigative Site, Glasgow

Unknown

Novartis Investigative Site, Glasgow

SE5 8AD

Novartis Investigative Site, London

W12 0HS

Novartis Investigative Site, London

W1G 9JF

Novartis Investigative Site, London

W2 1NY

Novartis Investigative Site, London

W2 1PG

Novartis Investigative Site, London

M13 9WL

Novartis Investigative Site, Manchester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Banner Alzheimer's Institute

OTHER

collaborator

National Institute on Aging (NIA)

NIH

collaborator

Amgen

INDUSTRY

lead

Novartis Pharmaceuticals

INDUSTRY