480
Participants
Start Date
November 30, 2015
Primary Completion Date
April 30, 2020
Study Completion Date
April 30, 2020
CAD106 Immunotherapy
Participants will be given i.m. injections at Weeks 1, 7, 13 and quarterly i.m. injections (every 13 weeks) thereafter, until the last injection 3 month prior to completion of the Treatment Epoch.
Placebo to CAD106
Participants will be given i.m. injections at Weeks 1, 7, 13 and quarterly i.m. injections (every 13 weeks) thereafter, until the last injection 3 month prior to completion of the Treatment Epoch.
CNP520
CNP520 50 mg capsule p.o. for the duration of the Treatment Epoch.
Placebo to CNP520
Placebo to CNP520 p.o. for the duration of the Treatment Epoch
Alum
Alum was mixed with reconstituted CAD106 as adjuvant therapy to maximize the effectiveness of CAD106
Novartis Investigative Site, Darlinghurst
Novartis Investigative Site, Leuven
Novartis Investigative Site, Heidelberg Heights
Novartis Investigative Site, Basel
Novartis Investigative Site, Nedlands
Novartis Investigative Site, Ghent
NYU Langone Medical Center, New York
The Nathan S. Kline Institute, Orangeburg
The Memory Center of Northeastern New York, Latham
Novartis Investigative Site, Berlin
University of Rochester Medical Center, Rochester
The Clinical Trial Center, LLC, Jenkintown
Abington Neurological Associates, Willow Grove
Novartis Investigative Site, Philadelphia
Novartis Investigative Site, Donostia / San Sebastian
Georgetown University, Washington D.C.
Novartis Investigative Site, Washington D.C.
Novartis Investigative Site, Turku
Novartis Investigative Site, Kiel
Triad Clinical Trials, LLC, Greensboro
Duke University Medical center, Durham
Novartis Investigative Site, Pozuelo de Alarcón
Alzheimer's Memory Center, Charlotte
Roper St. Francis - CBRI, Charleston
NeuroStudies, Decatur
Novartis Investigative Site, Atlanta
Medical Research & Health Education Foundation, Inc., Columbus
Progressive Medical Research, Port Orange
Novartis Investigative Site, Jacksonville
Meridien Research, Maitland
Novartis Investigative Site, Orlando
Compass Research, Orlando
Merritt Island Medical Research, Merritt Island
University of Miami, Miami
Mount Sinai Medical Center - The Wien Center, Miami Beach
Florida Atlantic University, Clinical Translational Research Unit, Boca Raton
Brain Matters Research, Delray Beach
USF Health Byrd Alzheimer's Institute, Tampa
Novartis Investigative Site, Göttingen
Novartis Investigative Site, Nashville
Novartis Investigative Site, Knoxville
CNS Healthcare, Memphis
Sanders Brown Center on Aging, University of Kentucky, Lexington
Novartis Investigative Site, Columbus
University Hospitals Cleveland Medical Center / Case Western Reserve University, Beachwood
Novartis Investigative Site, Centerville
Indiana University, Indianapolis
Novartis Investigative Site, Münster
Novartis Investigative Site, Kalamazoo
Novartis Investigative Site, Cologne
The Medical College of WI, Milwaukee
Novartis Investigative Site, Saint Paul
Novartis Investigative Site, Siegen
Rush University Medical Center, Chicago
Great Lakes Clinical Trials, Chicago
Novartis Investigative Site, St Louis
University of Kansas Alzheimer's Disease Center, Fairway
Via Christi Research, Wichita
Novartis Investigative Site, Mannheim
Novartis Investigative Site, Böblingen
IPS Research Company, Oklahoma City
Novartis Investigative Site, Oklahoma City
Kerwin Research Center & Memory Care, Dallas
Houston Methodist Hospital, Houston
University of Texas Health Science Center, Houston, Houston
Clinical Trial Network, Houston
Senior Adults Specialty Research, Austin
Novartis Investigative Site, Basalt
Advanced Clinical Research, Meridian
Banner Alzheimer's Institute, Phoenix
Novartis Investigative Site, Phoenix
Novartis Investigative Site, Scottsdale
Banner Sun City Research Institute, Sun City
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas
University of Southern California Keck School of Medicine Alzheimer Disease Research Center, Los Angeles
California Neuroscience Research Medical Group, Inc., Sherman Oaks
Novartis Investigative Site, San Diego
Novartis Investigative Site, Temecula
Irvine Center for Clinical Research, Irvine
ATP Clinical Research, Inc., Costa Mesa
Syrentis Clinical Research, Santa Ana
Novartis Investigative Site, Wenzenbach
Novartis Investigative Site, Palo Alto
Novartis Investigative Site, Bayreuth
Novartis Investigative Site, Sebastopol
Memory Health Center at Summit Research Network, Portland
Universal Research Group, Tacoma
Yale University Alzheimer's Disease Research Unit, New Haven
New England Institute for Clinical Research, Stamford
JEM Research Institute, Atlantis
Novartis Investigative Site, Bangor
Novartis Investigative Site, Boston
Novartis Investigative Site, Boston
Memory Disorders Program, Department of Neurological Sciences, University of Nebraska Medical Center, Omaha
Memory Enhancement Center, Eatontown
Butler Hospital Memory and Aging Program, Providence
The Memory Clinic, Bennington
Okanagan Clinical Trials, Kelowna
Novartis Investigative Site, Kentville
Novartis Investigative Site, Halifax
Novartis Investigative Site, London
Toronto Memory Program, Toronto
The Centre for Memory and Aging, Toronto
Novartis Investigative Site, Toronto
Novartis Investigative Site, Gatineau
Novartis Investigative Site, Québec
Novartis Investigative Site, Sherbrooke
Novartis Investigative Site, Sherbrooke
Novartis Investigative Site, Halle
Novartis Investigative Site, Leipzig
Novartis Investigative Site, Amsterdam
Novartis Investigative Site, Terrassa
Novartis Investigative Site, Barcelona
Novartis Investigative Site, Barcelona
Novartis Investigative Site, Westbruy on Trym
Novartis Investigative Site, Exeter
Novartis Investigative Site, Plymouth
Novartis Investigative Site, Guildford
Novartis Investigative Site, Avon
Novartis Investigative Site, Birmingham
Novartis Investigative Site, Dundee
Novartis Investigative Site, Glasgow
Novartis Investigative Site, Glasgow
Novartis Investigative Site, London
Novartis Investigative Site, London
Novartis Investigative Site, London
Novartis Investigative Site, London
Novartis Investigative Site, London
Novartis Investigative Site, Manchester
Lead Sponsor
Collaborators (1)
Banner Alzheimer's Institute
OTHER
National Institute on Aging (NIA)
NIH
Amgen
INDUSTRY
Novartis Pharmaceuticals
INDUSTRY