NCT02562872View on ClinicalTrials.gov

DSM265 Prophylaxis of Plasmodium Falciparum Malaria

PHASE1CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

March 31, 2016

Primary Completion Date

May 31, 2017

Study Completion Date

May 31, 2017

Conditions
Healthy
Interventions
DRUG

DSM265

DSM265 400 mg single oral dose

DRUG

Placebo

Placebo to match DSM265, single oral dose

BIOLOGICAL

Sporozoites

Direct venous inoculation of 3200 cryopreserved Plasmodium falciparum (NF54 strain) sporozoites

BIOLOGICAL

Infective mosquito bite

Five single bites by laboratory reared female Anopheles stephensi mosquitoes carrying Plasmodium falciparum

Trial Locations (1)

98109

Fred Hutchinson Cancer Research Center - Prevention Center, Seattle

Sponsors
All Listed Sponsors
collaborator

Fred Hutchinson Cancer Center

OTHER

collaborator

United States Department of Defense

FED

collaborator

Center for Infectious Disease Research

UNKNOWN

lead

Medicines for Malaria Venture

OTHER