Proton Pump Inhibitors and Risk of Community-acquired Pneumonia

CompletedOBSERVATIONAL
Enrollment

4,238,504

Participants

Timeline

Start Date

September 30, 2011

Primary Completion Date

February 29, 2012

Study Completion Date

February 29, 2012

Conditions
Gastroesophageal Reflux Disease (GERD)Community-acquired Pneumonia
Interventions
DRUG

esomeprazole

Exposure to esomeprazole (ATC A02BC05, B01AC56, M01AE52, A02BD06) will be defined as a prescription for esomeprazole on the same day as a ≥ 30 day NSAID prescription.

DRUG

omeprazole

Exposure to omeprazole (ATC A02BC01, A02BD01) will be defined as a prescription for omeprazole on the same day as a ≥ 30 day NSAID prescription.

DRUG

pantoprazole

Exposure to pantoprazole (ATC A02BC02, A02BD04) will be defined as a prescription for pantoprazole on the same day as a ≥ 30 day NSAID prescription.

DRUG

lansoprazole

Exposure to lansoprazole (ATC A02BC03, A02BD07, A02BD03, A02BD02) will be defined as a prescription for lansoprazole on the same day as a ≥ 30 day NSAID prescription.

DRUG

rabeprazole

Exposure to rabeprazole (ATC A02BC04) will be defined as a prescription for rabeprazole on the same day as a ≥ 30 day NSAID prescription.

DRUG

cimetidine

Exposure to cimetidine (ATC A02BA01) will be defined as a prescription for cimetidine on the same day as a ≥ 30 day NSAID prescription.

DRUG

ranitidine

Exposure to ranitidine (A02BA02) will be defined as a prescription for ranitidine on the same day as a ≥ 30 day NSAID prescription.

DRUG

famotidine

Exposure to famotidine (A02BA03) will be defined as a prescription for famotidine on the same day as a ≥30 day NSAID prescription.

DRUG

nizatidine

Exposure to nizatidine (A02BA04) will be defined as a prescription for nizatidine on the same day as a ≥ 30 day NSAID prescription.

DRUG

niperotidine

Exposure to niperotidine (A02BA05) will be defined as a prescription for niperotidine on the same day as a ≥ 30 day NSAID prescription.

DRUG

roxatidine

Exposure to roxatidine (A02BA06) will be defined as a prescription for roxatidine on the same day as a ≥ 30 day NSAID prescription.

DRUG

ranitidine bismuth citrate

Exposure to ranitidine bismuth citrate (A02BA07) will be defined as a prescription for ranitidine bismuth citrate on the same day as a ≥ 30 day NSAID prescription.

DRUG

lafutidine

Exposure to lafutidine (A02BA08) will be defined as a prescription for lafutidine on the same day as a ≥ 30 day NSAID prescription.

DRUG

cimetidine combinations

Exposure to cimetidine combinations (A02BA51) will be defined as a prescription for cimetidine combinations on the same day as a ≥ 30 day NSAID prescription.

DRUG

famotidine combinations

Exposure to famotidine combinations (A02BA53) will be defined as a prescription for famotidine combinations on the same day as a ≥ 30 day NSAID prescription.

Trial Locations (1)

H3T1E2

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal

All Listed Sponsors
collaborator

Drug Safety and Effectiveness Network, Canada

OTHER

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

Canadian Network for Observational Drug Effect Studies, CNODES

OTHER

NCT02555852 - Proton Pump Inhibitors and Risk of Community-acquired Pneumonia | Biotech Hunter | Biotech Hunter