Safety and Efficacy Study of CC-486 With MK-3475 to Treat Locally Advanced or Metastatic Non-small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

October 9, 2015

Primary Completion Date

April 13, 2017

Study Completion Date

July 7, 2025

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

CC-486

CC-486 will be administered orally at a dose of 300 mg daily on days 1-14 of each 21-day cycle.

DRUG

Pembrolizumab

Pembrolizumab will be administered as a 30-minute IV infusion on day 1 of each 21-day cycle.

DRUG

Placebo

Placebo will be administered orally daily on days 1-14 of each 21-day cycle.

Trial Locations (33)

10011

Local Institution - 006, New York

10016

NYU Langone Medical Center, New York

13125

Local Institution - 302, Berlin

13915

Local Institution - 200, Marseille

15562

Local Institution - 903, Athens

20057

Georgetown University Medical Center, Washington D.C.

20132

Local Institution - 602, Milan

20133

Local Institution - 606, Milan

28034

Local Institution - 703, Madrid

28040

Local Institution - 701, Madrid

Local Institution - 704, Madrid

28041

Local Institution - 706, Madrid

28100

Local Institution - 600, Novara

30607

University Cancer and Blood Center, LLC, Athens

31059

Local Institution - 203, Toulouse

33081

Local Institution - 601, Aviano

46014

Local Institution - 700, Valencia

48903

Local Institution - 705, Barakaldo

50937

Local Institution - 304, Cologne

63110

Washington Univ School of Medicine, St Louis

64132

Research Medical Center, Kansas City

69008

Local Institution - 204, Lyon

73730

Local Institution - 300, Esslingen am Neckar

74245

Local Institution - 301, Löwenstein

80131

Local Institution - 603, Napoli, Campania

85304

Palo Verde Hematology Oncology, Glendale

90095

UCLA Hematology Oncology, Los Angeles

94805

Local Institution - 201, Villejuif

95122

Local Institution - 604, Catania

11733-3456

North Shore Hematology Oncology Associates, East Setauket

37232-6307

Vanderbilt Univ Medical Center, Nashville

00128

Local Institution - 605, Roma

08035

Local Institution - 702, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY