750
Participants
Start Date
September 2, 2015
Primary Completion Date
December 31, 2026
Study Completion Date
December 31, 2027
Viral Specific VST Infusion
"VSTs will be infused into immunocompromised patients with evidence of viral infection or reactivation defined as any of the following:~* Blood adenovirus PCR ≥ 1,000~* Blood CMV PCR ≥ 500~* Blood EBV PCR ≥ 9,000~* Plasma BKV PCR \>1,000~* Plasma JC Virus PCR \> 1,000~* Evidence of invasive adenovirus infection or disease, defined as the presence of adenoviral positivity by PCR or culture in one or more sites~* Evidence of invasive CMV infection, eg pneumonitis, retinitis, colitis~* Evidence of invasive EBV disease/infection, EBV-associated lymphoproliferation (EBV-LPD) defined as proven EBV-LPD by biopsy or probable EBV-LPD defined as an elevated EBV DNA level in the blood associated with clinical symptoms (adenopathy or fever or masses on imaging) but without biopsy confirmation, or EBV-associated malignancies~* Evidence of symptomatic BK virus infection, which may include symptomatic hemorrhagic cystitis, or BK nephropathy~* Evidence of PML or other CNS infection due to JC virus"
RECRUITING
The Ohio State University Wexner Medical Center - James Cancer Hospital, Columbus
RECRUITING
Akron Children's Hospital, Akron
COMPLETED
University of Cincinnati Medical Center, Cincinnati
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
Children's Hospital Medical Center, Cincinnati
OTHER